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Risarestat - 98%, high purity , CAS No.79714-31-1

Grade & Purity:

≥98%

Cas Number: 79714-31-1
Molecular Weight: 323.41
PubChem CID: 133264

In stock

Item Number

R647182

Grouped product items
SKU	Size	Availability	Price
R647182-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$500.90
R647182-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
R647182-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,800.90
R647182-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,000.90
R647182-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,600.90

View related series

Aldose Reductase (31) Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860)

Synonyms	5-[3-ethoxy-4-(pentyloxy)phenyl]-2,4-thiazolidinedione \| SCHEMBL1814433 \| HY-16433 \| CAS-79714-31-1 \| Q27088451 \| Risarestat \| MS-24804 \| 5-(3-Ethoxy-4-(pentyloxy)phenyl)-2,4-thiazolidinedione \| 5-(3-ethoxy-4-pentoxyphenyl)-1,3-thiazolidine-2,4-dione \| CS
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Risarestat (CT-112), an aldose reductase inhibitor, is developed for the treatment of diabetic complications. In Vivo Risarestat inhibits the accumulation of dulcitol in a dose-dependent manner, except for the 1.0% solution which has an activity comparable to the 0.25% solution . Risarestat peaks in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminishes time-dependently over a period of 24 hours. Risarestat remains detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation. The anterior surface area of superficial cells in the group treated with Risarestat is significantly decreases from a mean value of 881 to 728 microns 2 . Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm 2. Animals treated with Risarestat shows a significant increase in the mean blinkresponse compared to untreated galactose-fed rats and does not differ significantly from controls towards the completion of the 7 month study. Animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Phenol ethers
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Phenol ethers
Alternative Parents	Phenoxy compounds Thiazolidinediones Alkyl aryl ethers Dicarboximides Thiocarbamic acid derivatives Organic carbonic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Phenoxy compound - Phenol ether - Alkyl aryl ether - Thiazolidinedione - Monocyclic benzene moiety - Dicarboximide - Thiazolidine - Thiocarbamic acid derivative - Carbonic acid derivative - Organoheterocyclic compound - Ether - Carboxylic acid derivative - Azacycle - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

IUPAC Name	5-(3-ethoxy-4-pentoxyphenyl)-1,3-thiazolidine-2,4-dione
INCHI	InChI=1S/C16H21NO4S/c1-3-5-6-9-21-12-8-7-11(10-13(12)20-4-2)14-15(18)17-16(19)22-14/h7-8,10,14H,3-6,9H2,1-2H3,(H,17,18,19)
InChIKey	CRPGRUONUFDYBG-UHFFFAOYSA-N
Smiles	CCCCCOC1=C(C=C(C=C1)C2C(=O)NC(=O)S2)OCC
Isomeric SMILES	CCCCCOC1=C(C=C(C=C1)C2C(=O)NC(=O)S2)OCC
Alternate CAS	79714-31-1
PubChem CID	133264
MeSH Entry Terms	5-(3-ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione;CT 112;CT-112;risarestat
Molecular Weight	323.41

Solubility	DMSO : 105 mg/mL (324.67 mM; Need ultrasonic)
Molecular Weight	323.400 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	323.119 Da
Monoisotopic Mass	323.119 Da
Topological Polar Surface Area	89.900 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	390.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Risarestat - 98%, high purity , CAS No.79714-31-1

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