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RIPA-56 - 98%, high purity , CAS No.1956370-21-0, Inhibitor of receptor interacting serine/threonine kinase 1

COA COA
In stock
Item Number
R413493
Grouped product items
SKU Size
Availability
 Price Qty
R413493-5mg
5mg
3
$39.90
R413493-10mg
10mg
2
$64.90
R413493-25mg
25mg
1
$146.90
R413493-50mg
50mg
1
$169.90
R413493-100mg
100mg
1
$299.90
R413493-200mg
200mg
1
$508.90
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RIP kinase Inhibitors

View related series
Apoptosis (4276) Extrinsic Pathway (436) receptor interacting serine/threonine kinase 1 Inhibitor (26) RIP kinase (65)

Basic Description

Synonyms Butanamide,N-​hydroxy-​2,​2-​dimethyl-​N-​(phenylmethyl)​-
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.RIPA-56 is a type III kinase inhibitor with stable metabolism. By locking RIP1 in the inactive form, it targets receptor-interacting protein-1 kinase (RIP1; RIPK1) in a
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of receptor interacting serine/threonine kinase 1
Product Description

Information

RIPA-56 RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.


Targets

RIP1 (Cell-free) 13 nM


In vitro

RIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC50 of 13 nM. It showed no inhibition of RIP3 kinase activity at a 10 µM concentration. RIPA-56 does not inhibit IDO activity at a concentration of 200 µM, which represents an estimated 10,000-fold selectivity window based on the RIP1 ADP-Glo activity of 13 nM.


In vivo

RIPA-56 has an impressive PK profile in mice, with a 3.1 h half-life, 22% oral bioavailability (PO), and 100% bioavailability from intraperitoneal injection (IP). RIPA-56 has great ability in transporting across blood brain barrier. In the SIRS mice disease model, RIPA-56 efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Benzene and substituted derivatives
Alternative Parents Hydroxamic acids  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Monocyclic benzene moiety - Hydroxamic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
External Descriptors Not available

Associated Targets(Human)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1548 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver (3974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RIPK3 Tchem Receptor-interacting serine/threonine-protein kinase 3 (468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MLKL Tchem Mixed lineage kinase domain-like protein (71 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEF (1005 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Brain (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772952
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772952
IUPAC Name N-benzyl-N-hydroxy-2,2-dimethylbutanamide
INCHI InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3
InChIKey AVYVHIKSFXVDBG-UHFFFAOYSA-N
Smiles CCC(C)(C)C(=O)N(CC1=CC=CC=C1)O
Isomeric SMILES CCC(C)(C)C(=O)N(CC1=CC=CC=C1)O
PubChem CID 121439991
Molecular Weight 221.3

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number Certificate Type Date Item
F2306502 Certificate of Analysis Apr 07, 2023 R413493
F2306494 Certificate of Analysis Apr 07, 2023 R413493
F2306495 Certificate of Analysis Apr 07, 2023 R413493
F2306499 Certificate of Analysis Apr 07, 2023 R413493
F2306503 Certificate of Analysis Apr 07, 2023 R413493
F2306496 Certificate of Analysis Apr 07, 2023 R413493
F2306497 Certificate of Analysis Apr 07, 2023 R413493
F2306498 Certificate of Analysis Apr 07, 2023 R413493
F2306493 Certificate of Analysis Apr 07, 2023 R413493
F2306504 Certificate of Analysis Apr 07, 2023 R413493
F2306500 Certificate of Analysis Apr 07, 2023 R413493
F2306501 Certificate of Analysis Apr 07, 2023 R413493

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Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 44 mg/mL (198.82 mM); Ethanol: 44 mg/mL (198.82 mM); Water: Insoluble;
Molecular Weight 221.290 g/mol
XLogP3 2.500
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 4
Exact Mass 221.142 Da
Monoisotopic Mass 221.142 Da
Topological Polar Surface Area 40.500 Ų
Heavy Atom Count 16
Formal Charge 0
Complexity 232.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. RIPA-56, Inhibitor of receptor interacting serine/threonine kinase 1
    RIPA-56, Inhibitor of receptor interacting serine/threonine kinase 1

    Starting at $172.90

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