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Rilematovir - 98%, high purity , Fusion glycoprotein F0 inhibitor, CAS No.1383450-81-4, Fusion glycoprotein F0 inhibitor

COA

Grade & Purity:

≥98%

Cas Number: 1383450-81-4
Molecular Weight: 500.92
PubChem CID: 118892432

In stock

Item Number

R648987

Grouped product items
SKU	Size	Availability	Price
R648987-5mg	5mg	3	$35.90
R648987-10mg	10mg	3	$59.90
R648987-25mg	25mg	2	$119.90
R648987-50mg	50mg	1	$179.90
R648987-100mg	100mg	1	$277.90

View related series

Anti-infection (2803) RSV (40) Virus (1811)

Basic Description

Synonyms	Rilematovir \| 3-((5-Chloro-1-(3-(methylsulfonyl)propyl)-1H-indol-2-yl)methyl)-1-(2,2,2-trifluoroethyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one \| Rilematovir [INN] \| JNJ-53718678 \| NQ99E8OH3P \| JNJ-678
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Rilematovir (JNJ-678) is a novel fusion protein inhibitor. Rilematovir has the potential for respiratory syncytial virus (RSV) research.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	INHIBITOR
Mechanism of action	Fusion glycoprotein F0 inhibitor
Product Description	Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Imidazopyridines
    - Subclass Imidazopyridinones

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Imidazopyridines
Subclass	Imidazopyridinones
Intermediate Tree Nodes	Not available
Direct Parent	Imidazopyridinones
Alternative Parents	N-alkylindoles Indoles Imidazo-[4,5-c]pyridines Pyridinones Substituted pyrroles N-substituted imidazoles Benzenoids Aryl chlorides Sulfones Heteroaromatic compounds Ureas Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-alkylindole - Imidazopyridinone - Imidazo-[4,5-c]pyridine - Indole or derivatives - Indole - Pyridinone - Benzenoid - Substituted pyrrole - Pyridine - N-substituted imidazole - Aryl halide - Aryl chloride - Heteroaromatic compound - Sulfonyl - Sulfone - Pyrrole - Imidazole - Azole - Urea - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as imidazopyridinones. These are compounds containing an imidazopyridine moiety where the pyridine ring bears a ketone group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	2.9

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Human orthopneumovirus (392 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Respiratory syncytial virus (3434 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

F Fusion glycoprotein F0 (242 Activities)

Discover Target: F

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-[[5-chloro-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-(2,2,2-trifluoroethyl)imidazo[4,5-c]pyridin-2-one
INCHI	InChI=1S/C21H20ClF3N4O3S/c1-33(31,32)8-2-7-27-16(10-14-9-15(22)3-4-17(14)27)12-28-19-11-26-6-5-18(19)29(20(28)30)13-21(23,24)25/h3-6,9-11H,2,7-8,12-13H2,1H3
InChIKey	GTQTUABHRCWVLL-UHFFFAOYSA-N
Smiles	CS(=O)(=O)CCCN1C2=C(C=C(C=C2)Cl)C=C1CN3C4=C(C=CN=C4)N(C3=O)CC(F)(F)F
Isomeric SMILES	CS(=O)(=O)CCCN1C2=C(C=C(C=C2)Cl)C=C1CN3C4=C(C=CN=C4)N(C3=O)CC(F)(F)F
Alternate CAS	1383450-81-4
PubChem CID	118892432
MeSH Entry Terms	JNJ-53718678
Molecular Weight	500.92

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
I2414338	Certificate of Analysis	Sep 07, 2024	R648987
I2414286	Certificate of Analysis	Sep 07, 2024	R648987
I2414309	Certificate of Analysis	Sep 07, 2024	R648987
I2414310	Certificate of Analysis	Sep 07, 2024	R648987
I2414335	Certificate of Analysis	Sep 07, 2024	R648987
I2414311	Certificate of Analysis	Sep 07, 2024	R648987
I2414336	Certificate of Analysis	Sep 07, 2024	R648987
I2414312	Certificate of Analysis	Sep 07, 2024	R648987
I2414337	Certificate of Analysis	Sep 07, 2024	R648987
I2414334	Certificate of Analysis	Sep 07, 2024	R648987

Chemical and Physical Properties

Solubility	DMSO : 65 mg/mL (129.76 mM; Need ultrasonic)
Molecular Weight	500.900 g/mol
XLogP3	2.900
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	500.09 Da
Monoisotopic Mass	500.09 Da
Topological Polar Surface Area	83.900 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	825.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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Rilematovir - 98%, high purity , Fusion glycoprotein F0 inhibitor, CAS No.1383450-81-4, Fusion glycoprotein F0 inhibitor

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Alternative Products

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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