Determine the necessary mass, volume, or concentration for preparing a solution.
This is a demo store. No orders will be fulfilled.
| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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R101754-100mg
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100mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$64.90
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R101754-1g
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1g |
3
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$352.90
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R101754-5g
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5g |
3
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$1,587.90
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R101754-10g
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10g |
1
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$2,857.90
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R101754-25g
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25g |
3
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$6,429.90
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R101754-100g
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100g |
2
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$23,147.90
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R101754-500g
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500g |
2
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$104,162.90
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Antiviral nucleoside
| Synonyms | KBioSS_002331 | RBV | Ribavirin Teva | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide | Ribavirin [USAN:USP:INN:BAN] | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide | Varazid | 1-((2R,3R,4S,5R |
|---|---|
| Specifications & Purity | Moligand™, ≥98% |
| Biochemical and Physiological Mechanisms | A non interferon-inducing, broad spectrum antiviral nucleoside. Active metabolites interfere with viral replication. Shows antiviral activity against a number of viruses including Hepatitis C, influenza and polio. |
| Storage Temp | Store at 2-8°C |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Ribavirin is a non-interferon-inducing, broad spectrum antiviral nucleoside. Ribavirin is reported to be active against RSV, HIV, HCV, and other infectious agents. The compound’s metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Nucleosides, nucleotides, and analogues |
| Class | Triazole ribonucleosides and ribonucleotides |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Triazole ribonucleosides and ribonucleotides |
| Alternative Parents | Glycosylamines Pentoses 2-heteroaryl carboxamides Triazoles Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Primary carboxylic acid amides Oxacyclic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | N-ribosyl-1,2,4-triazole - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - 2-heteroaryl carboxamide - Monosaccharide - Azole - Tetrahydrofuran - Triazole - 1,2,4-triazole - Heteroaromatic compound - Carboxamide group - Secondary alcohol - Primary carboxylic acid amide - Carboxylic acid derivative - Oxacycle - Azacycle - Organoheterocyclic compound - Alcohol - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Primary alcohol - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as triazole ribonucleosides and ribonucleotides. These are nucleoside derivatives containing a ribose (or deoxyribose) moiety which is N-glycosylated to a triazole. Nucleotides have a phosphate group linked to the C5 carbon of the ribose (or deoxyribose) moiety. |
| External Descriptors | monocarboxylic acid amide - aromatic amide - 1-ribosyltriazole |
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| ALogP | -1.8 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504753559 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504753559 |
| IUPAC Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide |
| INCHI | InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 |
| InChIKey | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
| Smiles | C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N |
| Isomeric SMILES | C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N |
| WGK Germany | 3 |
| RTECS | XZ4250000 |
| PubChem CID | 37542 |
| Molecular Weight | 244.2 |
| Reaxy-Rn | 892462 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 12, 2024 | R101754 | |
| Certificate of Analysis | Nov 11, 2024 | R101754 | |
| Certificate of Analysis | Mar 26, 2024 | R101754 | |
| Certificate of Analysis | Mar 26, 2024 | R101754 | |
| Certificate of Analysis | Feb 26, 2024 | R101754 | |
| Certificate of Analysis | May 08, 2023 | R101754 | |
| Certificate of Analysis | Apr 11, 2023 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 | |
| Certificate of Analysis | Jun 28, 2022 | R101754 |
| Solubility | Soluble in water (20 mg/ml), DMSO (49 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and alcohol (slightly). |
|---|---|
| Specific Rotation[α] | -36 ° (C=1, H2O) |
| Melt Point(°C) | 176°C |
| Molecular Weight | 244.200 g/mol |
| XLogP3 | -1.800 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 3 |
| Exact Mass | 244.081 Da |
| Monoisotopic Mass | 244.081 Da |
| Topological Polar Surface Area | 144.000 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 304.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Weifeng Zhang, Hualong Deng, Yanfen Liu, Shaohong Chen, You Liu, Yuntao Zhao. (2023) Ribavirin inhibits peste des petits ruminants virus proliferation in vitro. VETERINARNI MEDICINA, 68 (12): ( 464–476). |
| 2. Xiang Liu, Bing-Ke Li, Qin-Xue Liu, Peng-Fei Li, Fei Ling, Gao-Xue Wang. (2024) In vivo and in vitro antiviral effect and mechanisms of rhein against nervous necrosis virus. AQUACULTURE, 579 (740207). |
| 3. Fuying Li, Shiying Chen, Haoxin Hu, Chengfeng Liang, Shiyu Sun, Can Jin, Fenghua Chen. (2023) Crystallization Selectivity of Ribavirin Solution and Amorphous Phase. MOLECULES, 28 (17): (6320). |
| 4. Hongmei Dong, Lifeng Ding, Boyuan Ran, Yongbo Song, Ruihong Wang, Lu Zhao, Yulan Niu. (2023) A study on the anti-corrosion mechanism of the eco-friendly inhibitor Ribavirin on Q235 steel in an acidic chloride environment. International Journal of Electrochemical Science, 18 (100250). |
| 5. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). |
| 6. Yunlong Yan, Maoxi Huang, Li Wang, Wei Xue, Xin Xie, Xiangyang Li. (2022) Insights into a rapid screening method for anti-cucumber mosaic virus compounds. JOURNAL OF VIROLOGICAL METHODS, 301 (114402). |
| 7. Xin Mao, Shuyin Gu, Huiting Sang, Yilu Ye, Jingyan Li, Yunxia Teng, Feiyu Zhang, Qinhai Ma, Ping Jiang, Zifeng Yang, Weizhong Huang, Shuwen Liu. (2021) Essential Oil-Rich Chinese Formula Luofushan-Baicao Oil Inhibits the Infection of Influenza A Virus through the Regulation of NF-κB P65 and IRF3 Activation. Evidence-based Complementary and Alternative Medicine, 2021 (5547424). |
| 8. Ren Le, Qi Shuo, Khan Imran Mahmood, Wu Shijia, Duan Nuo, Wang Zhouping. (2021) Screening and application of a broad-spectrum aptamer for acyclic guanosine analogues. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (19): (4855-4863). |
| 9. Xiaoyu Liu, Yuntao Hong, Shunke Ding, Wei Jin, Shengkun Dong, Rong Xiao, Wenhai Chu. (2021) Transformation of antiviral ribavirin during ozone/PMS intensified disinfection amid COVID-19 pandemic. SCIENCE OF THE TOTAL ENVIRONMENT, 790 (148030). |
| 10. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi. (2021) Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. PHARMAZIE, 76 (5): (195-201). |
| 11. Li Dengliang, Cui Zhanding, Li Guohua, Zhang Liangting, Zhang Ying, Zhao Han, Zhang Shuang, Guo Yanbing, Zhao Yanli, Men Fanxing, Zhao Shihui, Shao Jiang, Du Dongju, Huang Hailong, Wang Kai, Hu Guixue, Li Tiansong, Zhao Yongkun. (2020) Antiviral effect of copper chloride on feline calicivirus and synergy with ribavirin in vitro. BMC Veterinary Research, 16 (1): (1-9). |
| 12. Xiaoming Ma, Shan He, Ying Zhang, Jianguo Xu, Huifang Zhang, Zhen Wang, Jun Xue, Xun Li, Wenbo Yu, Xiaolin Fan. (2020) Signal-off tuned signal-on (SF-T-SN) colorimetric immunoassay for amantadine using activity-metalmodulated peroxidase-mimicking nanozyme. SENSORS AND ACTUATORS B-CHEMICAL, 311 (127933). |
| 13. Xiao-Bo Yu, Kai Hao, Jing Li, Xiao-Hui Chen, Gao-Xue Wang, Fei Ling. (2018) Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation. RESEARCH IN VETERINARY SCIENCE, 117 (37). |
| 14. Xiao-Bo Yu, Xiao-Hui Chen, Fei Ling, Kai Hao, Gao-Xue Wang, Bin Zhu. (2016) Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. ANTIVIRAL RESEARCH, 131 (156). |
| 15. X. X. Zhao, B. F. Yu, H. X. Zhang. (2014) Effects of zinc ion on the selectivity and template removal of molecularly imprinted polymers for sulfadiazine. Analytical Methods, 6 (19): (8059-8062). |
| 16. Maosheng He, Ying Yan, Xiang Liu, Linhan Li, Bin Yang, Mingzhu Liu, Qing Yu, Erlong Wang, Pengfei Li, Tianqiang Liu, Gaoxue Wang. (2024) A nanobody-mediated drug system against largemouth bass virus delivered by bacterial nanocellulose in Micropterus salmoides. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 266 (131146). |
| 17. Yijun Jia, Zhao Zhao, Leyang Chen, Yongqi Liu, Bin Zhu. (2025) Carbon Nanotube-Based Drug Delivery System Increases Drug Content and Promotes Immune Response in Mandarin Fish. Fishes, 10 (3): (92). |
| 18. Ying Xu, Tingting Zhang, Shimei Mu, Yanqun Peng, Duanpu Wu, Li Yang, Qing Li, Zengxue Wu, Jian Zhang. (2025) Discovery of Arbutin as Novel Potential Antiviral Agent Against Tomato Yellow Leaf Curl Virus. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 73 (7): (3967-3976). |
| 19. Shi Yanfeng, Li Bingxu, Shi Yuzhi, Sun Yuanyuan, Ding Botao, Zhang Yanhao, Zhang Xu, Zhang Zhibin, Li Fulin. (2024) Effect of Hydrochemical Factors on the Retention and Transport of Ribavirin in Saturated Sand and Limestone Porous Media. WATER AIR AND SOIL POLLUTION, 235 (6): (1-12). |
| 20. Xiaoyan Chen, Jiangdong Cui, Xinyu Yang, Taoyue Yuan, Jiacheng Ge, Mengtao Ma, Shunke Ding, Wenhai Chu. (2025) Enhanced removal of phenolic contaminants with permanganate oxidation mediated by SiO2@TEMPO: Performance, transformation pathway, and selectivity. CHEMICAL ENGINEERING JOURNAL, 503 (158210). |
| 21. Zhanding Cui, Jinlong Liu, Jinlong Wang, Jing Zhang, Yimei Cao, Kun Li, Zhixun Zhao, Hong Yuan, Xingwen Bai, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Dong Li, Qiang Zhang, Zaixin Liu, Kai Li, Tong Xu, Zengjun Lu. (2025) Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro. Frontiers in Nutrition, 11 |
| 22. Haichuan Zhang, Jiawei Li, Shanshan Ye, Xiyang Zou, Rongxin Fei, Xinyu Hu, Ji Li. (2024) High-efficiently utilizing micro-nano ozone bubbles to enhance electro-peroxone process for rapid removal of trace pharmaceutical contaminants from hospital wastewater. WATER RESEARCH, 259 (121896). |
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| 24. Zilin Wu, Min Huang, Junmei Jiang, Chun Zhang, Gefei Hao, Moxian Chen, Qing X. Li, Mengao Jia, Junfeng Liu, Xiangyang Li. (2024) Ningnanmycin Activates Defense Systems against Potato Virus Y in Nicotiana benthamiana. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 72 (48): (26633-26643). |
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