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RHC-80267 - ≥98%, high purity , CAS No.83654-05-1, Inhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β

COA COA
En stock
Item Number
R274741
Articles du produit groupé
SKU Taille
Disponibilité
 Prix Qté
R274741-10mg
10mg
2
88,90$US
R274741-25mg
25mg
2
177,90$US
R274741-50mg
50mg
2
296,90$US
R274741-250mg
250mg
2
1 336,90$US
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Bulk Order  SDS  DATASHEET  Specification Sheet

Selective diacylglycerol lipase inhibitor

View related series
Acyltransferase (66) Class A GPCR (4138) COX (258) Diacylglycerol lipase α Inhibitor (6) Diacylglycerol lipase β Inhibitor (6) GPCR/G Protein (3172) Immunology/Inflammation (1929) Lipid metabolism (1912) mAChR (182) Metabolic Enzyme/Protease (4860) Neuronal Signaling (3320) Phospholipase (108)

Description générale

Synonymes BCBcMAP01_000181 | CS-0028444 | HMS3676J18 | HMS3268I22 | SCHEMBL23015112 | (Hexane-1,6-diyldiimino)bis{[(cyclohexylideneamino)oxy]methanone} | BSPBio_001074 | CyclohexanoneO-((6-((((cyclohexylideneamino)oxy)carbonyl)amino)hexyl)carbamoyl)oxime | HMS3412J
Spécifications et pureté Moligand™, ≥98%
Mécanismes biochimiques et physiologiques Selective diacylglycerol lipase inhibitor (IC 50 = 4 μM). Enhances acetylcholine induced smooth muscle relaxation in vitro .
Température de stockage Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Grade Moligand™
Type d'action INHIBITOR
Mécanisme d'action Inhibitor of Diacylglycerol lipase α;Inhibitor of Diacylglycerol lipase β
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at Room Temperature. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Classe Carboximidic acids and derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Carboximidic acids and derivatives
Alternative Parents Propargyl-type 1,3-dipolar organic compounds  Organopnictogen compounds  Organooxygen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular Framework Aliphatic homomonocyclic compounds
Substituents Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aliphatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as carboximidic acids and derivatives. These are compounds containing a carboximidic group, with the general formula R-C(=NR1)OR2.
External Descriptors Not available

Cibles associées (humaines)

DAGLB Tchem Sn1-specific diacylglycerol lipase beta (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
DAGLA Tchem Sn1-specific diacylglycerol lipase alpha (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLA2G7 Tchem LDL-associated phospholipase A2 (1338 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MGLL Tchem Monoglyceride lipase (1909 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DAGLA Tchem Sn1-specific diacylglycerol lipase alpha (416 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCEH1 Tchem Neutral cholesterol ester hydrolase 1 (158 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABHD12 Tchem Monoacylglycerol lipase ABHD12 (195 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DAGLB Tchem Sn1-specific diacylglycerol lipase beta (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Faah Anandamide amidohydrolase (3907 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pla2g7 Platelet-activating factor acetylhydrolase (22 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Abhd16a Protein BAT5 (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lipe Hormone-sensitive lipase (209 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Abhd6 Monoacylglycerol lipase ABHD6 (221 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LIP1 LIP1, secretory lipase (Family 3) (15 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mécanismes d'action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name Références

Noms et identifiants

Pubchem Sid 504750841
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504750841
IUPAC Name (cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate
INCHI InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
InChIKey RXSVYGIGWRDVQC-UHFFFAOYSA-N
Smiles C1CCC(=NOC(=O)NCCCCCCNC(=O)ON=C2CCCCC2)CC1
Isomères SMILES C1CCC(=NOC(=O)NCCCCCCNC(=O)ON=C2CCCCC2)CC1
PubChem CID 5063
Poids moléculaire 394.6

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Article
F2518078 Certificate of Analysis Jun 24, 2025 R274741
H2218510 Certificate of Analysis Jun 05, 2023 R274741
H2218507 Certificate of Analysis Jun 05, 2023 R274741
H2218511 Certificate of Analysis Jun 05, 2023 R274741
H2218509 Certificate of Analysis Jun 05, 2023 R274741

Propriétés chimiques et physiques

Solubilité Soluble in DMSO to 50 mM and in ethanol to 50 mM
Poids moléculaire 394.500 g/mol
XLogP3 3.500
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 11
Exact Mass 394.258 Da
Monoisotopic Mass 394.258 Da
Topological Polar Surface Area 101.000 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 484.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Calculateurs de solution

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