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RG7388 - 98%, high purity , Tumour suppressor p53/oncoprotein Mdm2 inhibitor, CAS No.1229705-06-9, Tumour suppressor p53/oncoprotein Mdm2 inhibitor

1 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
R125598
Grouped product items
SKU Size
Availability
 Price Qty
R125598-5mg
5mg
2
$68.90
R125598-10mg
10mg
2
$117.90
R125598-25mg
25mg
1
$265.90
R125598-100mg
100mg
1
$484.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

View related series
Amino Acid/Protein Metabolism (1836) Apoptosis (4276) E1/E2/E3 Enzyme (112) Hydroxy PEG (472) Intrinsic Pathway (690) MDM-2/p53 (109) Metabolic Enzyme/Protease (4860) PROTAC linker (720)

Basic Description

Synonyms TVTXCJFHQKSQQM-LJQIRTBHSA-N | EN300-26181975 | RO5503781 | BP-25380 | 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid. | CLADRIBINE [MI] | UNII-5M84PX7JN2 | 4-((2
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Potent MDM2 inhibitor (IC50= 6 nM in binding assay, and 30 nM in cancer cell proliferation assay). Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor x
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type INHIBITOR
Mechanism of action Tumour suppressor p53/oncoprotein Mdm2 inhibitor
Product Description

Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Stilbenes
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Stilbenes
Alternative Parents Acylaminobenzoic acid and derivatives  Proline and derivatives  Alpha amino acid amides  M-methoxybenzoic acids and derivatives  Phenylpyrrolidines  Anilides  Methoxyanilines  Benzoic acids  Phenoxy compounds  Pyrrolidinecarboxamides  Anisoles  N-arylamides  Methoxybenzenes  Benzoyl derivatives  Aralkylamines  Chlorobenzenes  Fluorobenzenes  Alkyl aryl ethers  Aryl chlorides  Aryl fluorides  Pyrroles  Secondary carboxylic acid amides  Amino acids  Dialkylamines  Azacyclic compounds  Nitriles  Carboxylic acids  Hydrocarbon derivatives  Organic oxides  Organochlorides  Organofluorides  Carbonyl compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Stilbene - Acylaminobenzoic acid or derivatives - Proline or derivatives - Alpha-amino acid amide - M-methoxybenzoic acid or derivatives - 3-phenylpyrrolidine - Alpha-amino acid or derivatives - Benzoic acid - Benzoic acid or derivatives - Anilide - Methoxyaniline - Benzoyl - Phenoxy compound - Phenol ether - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Anisole - N-arylamide - Methoxybenzene - Aralkylamine - Chlorobenzene - Fluorobenzene - Halobenzene - Alkyl aryl ether - Benzenoid - Aryl chloride - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Pyrrolidine - Pyrrole - Secondary carboxylic acid amide - Amino acid - Carboxamide group - Amino acid or derivatives - Azacycle - Ether - Carboxylic acid derivative - Secondary aliphatic amine - Carboxylic acid - Secondary amine - Organoheterocyclic compound - Carbonitrile - Nitrile - Organic nitrogen compound - Carbonyl group - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Amine - Cyanide - Organic oxygen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors Not available

Product Properties

ALogP 4.3

Associated Targets(Human)

MDM2 Tchem E3 ubiquitin-protein ligase Mdm2 (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MDM2 Tchem p53-binding protein Mdm-2 (4545 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RKO (1376 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW480 (6023 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver microsomes (16955 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDM4 Tchem Protein Mdm4 (729 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Tumour suppressor p53/oncoprotein Mdm2 (2075 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SJSA-1 (970 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLM-14 (399 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLM-13 (2241 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver microsome (341 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504771165
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771165
IUPAC Name 4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid
INCHI InChI=1S/C31H29Cl2F2N3O4/c1-30(2,3)14-24-31(15-36,19-10-9-17(32)13-21(19)34)25(18-6-5-7-20(33)26(18)35)27(38-24)28(39)37-22-11-8-16(29(40)41)12-23(22)42-4/h5-13,24-25,27,38H,14H2,1-4H3,(H,37,39)(H,40,41)/t24-,25-,27+,31-/m0/s1
InChIKey TVTXCJFHQKSQQM-LJQIRTBHSA-N
Smiles CC(C)(C)CC1C(C(C(N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F
Isomeric SMILES CC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F
PubChem CID 53358942
Molecular Weight 616.48

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
I2205357 Certificate of Analysis Jun 20, 2024 R125598
I2205358 Certificate of Analysis Jun 20, 2024 R125598
I2205359 Certificate of Analysis Jun 20, 2024 R125598
I2205360 Certificate of Analysis Jun 20, 2024 R125598

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 61.65, Max Conc. mM: 100；DMSO (Slightly), Methanol (Slightly)
Molecular Weight 616.500 g/mol
XLogP3 4.300
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 8
Exact Mass 615.15 Da
Monoisotopic Mass 615.15 Da
Topological Polar Surface Area 111.000 Ų
Heavy Atom Count 42
Formal Charge 0
Complexity 1040.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Kang Chen, Xiu Xin, Lipeng Qiu, Wenpan Li, Guannan Guan, Gang Li, Mingxi Qiao, Xiuli Zhao, Haiyang Hu, Dawei Chen.  (2019)  Co-delivery of p53 and MDM2 inhibitor RG7388 using a hydroxyl terminal PAMAM dendrimer derivative for synergistic cancer therapy.  Acta Biomaterialia,  100  (118). 

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