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RG7112 - ≥98%, high purity , CAS No.939981-39-2, Inhibitor of MDM2 proto-oncogene

COA COA
In stock
Item Number
R127149
Grouped product items
SKU Size
Availability
 Price Qty
R127149-5mg
5mg
3
$117.90
R127149-10mg
10mg
3
$206.90
R127149-25mg
25mg
2
$414.90
R127149-50mg
50mg
1
$632.90
R127149-100mg
100mg
2
$939.90
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MDM1 inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Apoptosis (4276) E1/E2/E3 Enzyme (112) Intrinsic Pathway (690) MDM-2/p53 (109) MDM2 proto-oncogene Inhibitor (3) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms DTXSID60240182 | CCG-270414 | EX-A1686 | UNII-Q8MI0X869M | RG7112 (RO5045337) | CS-0330 | Q27287118 | R 7112 | R 7112 [WHO-DD] | RG-7112;RG 7112; RO-5045337; RO 5045337; RO5045337 | AKOS027282701 | Ro 5045337 | s7030 | A857519 | HY-10959 | METHANONE, ((4S
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Restoration of p53 activity by inhibiting the p53-MDM2 interaction may represent a novel approach to cancer treatment. RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. In cancer cells expressing
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of MDM2 proto-oncogene
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Stilbenes
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Stilbenes
Alternative Parents Piperazine carboxamides  Phenylpropanes  Phenoxy compounds  Phenol ethers  Alkyl aryl ethers  Chlorobenzenes  N-alkylpiperazines  Aryl chlorides  Sulfones  Imidazolines  Ureas  Trialkylamines  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Carboxamidines  Carboximidamides  Organochlorides  Carbonyl compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Stilbene - Phenylpropane - Piperazine-1-carboxamide - Phenol ether - Phenoxy compound - Alkyl aryl ether - Chlorobenzene - Halobenzene - N-alkylpiperazine - Benzenoid - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Piperazine - 1,4-diazinane - Sulfonyl - Sulfone - 2-imidazoline - Urea - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Carboxylic acid amidine - Amidine - Ether - Carbonyl group - Organic oxide - Hydrocarbon derivative - Amine - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors Not available

Associated Targets(Human)

MDM2 Tchem E3 ubiquitin-protein ligase Mdm2 (4 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MDM2 Tchem p53-binding protein Mdm-2 (4545 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RKO (1376 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW480 (6023 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver microsomes (16955 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SJSA-1 (970 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504771595
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771595
IUPAC Name [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone
INCHI InChI=1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1
InChIKey QBGKPEROWUKSBK-QPPIDDCLSA-N
Smiles CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
Isomeric SMILES CCOC1=C(C=CC(=C1)C(C)(C)C)C2=N[C@@]([C@@](N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
Alternate CAS 939981-39-2
PubChem CID 57406853
MeSH Entry Terms RG7112
Molecular Weight 727.78

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
I2227580 Certificate of Analysis Jul 10, 2024 R127149
I2227581 Certificate of Analysis Jul 10, 2024 R127149
I2227582 Certificate of Analysis Jul 10, 2024 R127149
I2227579 Certificate of Analysis Jul 10, 2024 R127149
I2227571 Certificate of Analysis Jul 10, 2024 R127149

Chemical and Physical Properties

Solubility DMSO
Molecular Weight 727.800 g/mol
XLogP3 7.300
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 10
Exact Mass 726.277 Da
Monoisotopic Mass 726.277 Da
Topological Polar Surface Area 90.900 Ų
Heavy Atom Count 49
Formal Charge 0
Complexity 1260.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

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