Remodelin hydrobromide - ≥98%, high purity , CAS No.1622921-15-6

Name: Remodelin hydrobromide - ≥98%, high purity , CAS No.1622921-15-6
Price: 97.9 USD
Availability: InStock

Grade & Purity:

In stock

Item Number

R413800

Grouped product items
SKU	Size	Availability	Price
R413800-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$97.90
R413800-25mg	25mg	3	$220.90
R413800-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$314.90
R413800-100mg	100mg	3	$567.90
R413800-200mg	200mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,020.90

Histone Acetyltransferase Inhibitors

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Synonyms	Remodelin HBr4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile,hydrobromide (1:1)
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Remodelin hydrobromide Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor. Targets NAT10 In vitro Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases.

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzonitriles
Intermediate Tree Nodes	Not available
Direct Parent	Benzonitriles
Alternative Parents	2,4-disubstituted thiazoles Heteroaromatic compounds Nitriles Hydrazones Azacyclic compounds Hydrocarbon derivatives Hydrobromides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzonitrile - 2,4-disubstituted 1,3-thiazole - Azole - Thiazole - Heteroaromatic compound - Organoheterocyclic compound - Nitrile - Carbonitrile - Hydrazone - Azacycle - Hydrobromide - Organonitrogen compound - Cyanide - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzonitriles. These are organic compounds containing a benzene bearing a nitrile substituent.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

IUPAC Name	4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;hydrobromide
INCHI	InChI=1S/C15H14N4S.BrH/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13;/h5-8,10H,1-4H2,(H,17,19);1H
InChIKey	XNWBCMSPDCSWSD-UHFFFAOYSA-N
Smiles	C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br
Isomeric SMILES	C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br
PubChem CID	86280479
Molecular Weight	363.28

Lot Number	Certificate Type	Date	Item
G2209339	Certificate of Analysis	Apr 07, 2025	R413800
G2209347	Certificate of Analysis	Apr 07, 2025	R413800

Basic Description

Solubility	Solubility (25°C) In vitro DMSO: 72 mg/mL warmed with 50ºC Water: bath (198.19 mM); Water: Insoluble; Ethanol: Insoluble;
Sensitivity	Moisture sensitive.
DMSO(mg / mL) Max Solubility	72
DMSO(mM) Max Solubility	198.1942303
Water(mg / mL) Max Solubility	＜1
Molecular Weight	363.300 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	362.02 Da
Monoisotopic Mass	362.02 Da
Topological Polar Surface Area	89.300 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	397.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2