JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

This is a demo store. No orders will be fulfilled.

Account

Settings

Language

྾

Home
Small Molecules & Compound Libraries
Signaling Pathways
Autophagy
Autophagy
Regorafenib Hydrochloride - 99%, high purity , CAS No.835621-07-3

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Regorafenib Hydrochloride - 99%, high purity , CAS No.835621-07-3

COA

Grade & Purity:

≥99%

Cas Number: 835621-07-3
Molecular Weight: 519.28
PubChem CID: 66577009
PubChem SID: 504771841

In stock

Item Number

R413198

Grouped product items
SKU	Size	Availability	Price
R413198-25mg	25mg	3	$70.90
R413198-50mg	50mg	3	$117.90
R413198-100mg	100mg	3	$177.90
R413198-500mg	500mg	2	$801.90
R413198-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,441.90

PDGFRβ Selective Inhibitors

View related series

Autophagy (1917) MAPK/ERK Pathway (546) PDGFR (109) Protein Tyrosine Kinase/RTK (1314) Raf (69) Receptor Tyrosine Kinase (1260) RET (39) VEGFR (187)

Basic Description

Synonyms	4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide--hydrogen chloride (1/1) \| Regorafenib HCl \| CS-0725 \| 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hy
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Regorafenib (Stivarga, BAY 73-4506) Hydrochloride is a multi-target inhibitor for VEGFR1, Murine VEGFR2/3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM, 4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Regorafenib (Stivarga, BAY 73-4506) Hydrochloride is a multi-target inhibitor forVEGFR1,Murine VEGFR2/3,PDGFRβ,Kit (c-Kit),RET (c-RET)andRaf-1with IC50 of 13 nM, 4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Targets RET (Cell-free assay); Raf-1 (Cell-free assay); Murine VEGFR2 (Cell-free assay); Kit (Cell-free assay); VEGFR1 (Cell-free assay) 34591,1.5 nM; 2.5 nM; 4.2 nM; 7 nM; 13 nM

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - Class Organooxygen compounds
    - Subclass Ethers

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
Class	Organooxygen compounds
Subclass	Ethers
Intermediate Tree Nodes	Not available
Direct Parent	Diarylethers
Alternative Parents	N-phenylureas Trifluoromethylbenzenes Pyridinecarboxamides 2-heteroaryl carboxamides Phenol ethers Phenoxy compounds Fluorobenzenes Chlorobenzenes Aryl fluorides Aryl chlorides Heteroaromatic compounds Ureas Secondary carboxylic acid amides Azacyclic compounds Organonitrogen compounds Organofluorides Organochlorides Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Diaryl ether - Trifluoromethylbenzene - N-phenylurea - Pyridinecarboxamide - Pyridine carboxylic acid or derivatives - 2-heteroaryl carboxamide - Phenoxy compound - Phenol ether - Chlorobenzene - Fluorobenzene - Halobenzene - Aryl chloride - Benzenoid - Monocyclic benzene moiety - Pyridine - Aryl halide - Aryl fluoride - Heteroaromatic compound - Urea - Secondary carboxylic acid amide - Carboxamide group - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Alkyl fluoride - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Carbonyl group - Hydrochloride - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Alkyl halide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	4.763
HBD Count	3
Rotatable Bond	6

Names and Identifiers

Pubchem Sid	504771841
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771841
IUPAC Name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;hydrochloride
INCHI	InChI=1S/C21H15ClF4N4O3.ClH/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26;/h2-10H,1H3,(H,27,31)(H2,29,30,32);1H
InChIKey	ACSWJKPZXNIVMY-UHFFFAOYSA-N
Smiles	CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.Cl
Isomeric SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.Cl
PubChem CID	66577009
Molecular Weight	519.28

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
F2222542	Certificate of Analysis	Apr 03, 2024	R413198
F2222535	Certificate of Analysis	Apr 03, 2024	R413198
F2222536	Certificate of Analysis	Apr 03, 2024	R413198
F2222543	Certificate of Analysis	Apr 03, 2024	R413198
F2222537	Certificate of Analysis	Apr 03, 2024	R413198

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (192.57 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	100
DMSO(mM) Max Solubility	192.574333692805
Water(mg / mL) Max Solubility	＜1
Molecular Weight	519.299 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	518.054 Da
Monoisotopic Mass	518.054 Da
Topological Polar Surface Area	92.400 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	686.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.