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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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rp167459-GMP-50μg
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50μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,419.90
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rp167459-GMP-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$11,359.90
|
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GMP, ≥95% (SDS-PAGE&SEC-HPLC), Active, E. coli, No tag, 22-195 aa
| Product Name | Recombinant Human Thrombopoietin GMP Protein |
|---|---|
| Synonyms | Megakaryocyte colony-stimulating factor | Megakaryocyte growth and development factor | megakaryocyte stimulating factor | MGDF | MGDFC-mpl ligand | MKCSF | MK-CSF | ML | MPL ligand | MPLLG | MGC163194 | Myeloproliferative leukemia virus oncogene ligand | |
| Grade | ActiBioPure™, Animal Free, Bioactive, Carrier Free, GMP, High Performance |
| Specifications & Purity | ActiBioPure™, Bioactive, GMP, Animal Free, Carrier Free, High performance, ≥95%(SDS-PAGE&SEC-HPLC) |
| Biochemical and Physiological Mechanisms | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Bioactivity | Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is 0.05-0.5 ng/mL. The specific activity of Recombinant Human Thrombopoietin is >1 x 10^7 units/mg, which is calibrated against the human Thrombopoietin reference standard (NIBSC code: 03/124). |
| Endotoxin Concentration | <0.1 EU/μg |
| Expression System | E. coli |
| Amino Acids | 22-195 aa |
| Sequence | SPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNEL |
| Protein Tag | No tag |
| N-terminal Sequence | Ala-Ser22-Pro-Ala-Pro-Pro-Ala-(Cys)-Asp-Leu |
| Accession # | NP_000451.1 |
| Predicted molecular weight | 18.7 kDa |
| SDS-PAGE | 19 kDa, under reducing conditions |
| Reconstitution | Reconstitute at 100-200 μg/mL in sterile, deionized water. |
|---|---|
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | A minimum of 12 months when stored at ≤ -20 ℃ as supplied. 1 month, 2 to 8 ℃ under sterile conditions after reconstitution. 3 months, ≤ -28 ℃ under sterile conditions after reconstitution. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycl |