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Recombinant Human NRG1/HRG1 Protein, >92%(SDS-PAGE), high purity

  • Expression System: HEK293
  • Accession #: Q02297
  • Protein Tag: C-His
  • Bioactivity: Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 20‑100 ng/mL.
  • Endotoxin Concentration: <0.1 EU/μg
In stock
Item Number
rp149423
Grouped product items
SKU Size
Availability
Price Qty
rp149423-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
rp149423-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$209.90
rp149423-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$319.90
rp149423-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,609.90

Animal Free, ≥95% (SDS-PAGE), Active, 293F, C-His tag, 20-241 aa

Basic Description

Product Name Recombinant Human NRG1/HRG1 Protein, >92%(SDS-PAGE), high purity
Synonyms Acetylcholine receptor-inducing activity | Acetylcholine receptor-inducing activity, CHICK, homolog of | ARIA | Breast cancer cell differentiation factor p45 | GGF | GGF2 | Glial growth factor | Heregulin | heregulin, alpha (45kD, ERBB2 p185-activator) |
Grade ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High Performance
Product Description

Purity
≥95% (SDS-PAGE)
Endotoxin level
<0.1 EU/ug
Function
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Specifications & Purity ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE)
Purity >92%(SDS-PAGE)
Bioactivity Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 20‑100 ng/mL.
Endotoxin Concentration <0.1 EU/μg
Expression System HEK293
Species Human
Amino Acids 20-241 aa
Sequence SGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKHHHHHH
Protein Tag C-His
Accession # Q02297
Predicted molecular weight 24.8 kDa
SDS-PAGE 40-43 kDa, under reducing conditions

Storage and Shipping

Shape Lyophilized
Reconstitution Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -20~-80℃ for more than 1 year. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Images

Recombinant Human NRG1/HRG1 Protein (rp149423) - Protein Bioactivity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED₅₀ for this effect is 77.6 ng/mL.

Recombinant Human NRG1/HRG1 Protein (rp149423) - SDS-PAGE
3 μg/lane of Recombinant Human NRG1/HRG1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 40 - 50 kDa.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

Reviews

Customer Reviews

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