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Recombinant Human NCAM-1/CD56 Protein

Grade & Purity:

≥90%(SDS-PAGE)

Expression System: CHO
Accession #: P13591
Protein Tag: C-His
Bioactivity: Testing in progress
Endotoxin Concentration: <1.0 EU/μg

In stock

Item Number

rp175917

Grouped product items
SKU	Size	Availability	Price
rp175917-10μg	10μg	≥10	$139.90
rp175917-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$499.90
rp175917-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,999.90

Animal Free, >90% SDS-PAGE, CHO, C-His tag, 20-603 aa

View related series

Click to view protein information: NCAM1

Accession#:P13591 (11) CD56 (14) Gene ID:4684 (12) NCAM1 (15)

Basic Description

Product Name	Recombinant Human NCAM-1/CD56 Protein
Synonyms	CD56/NCAM-1 \| CD56 antigen \| CD56 \| MSK39 \| NCAM1 \| N-CAM-1 \| NCAM-1 \| NCAMantigen recognized by monoclonal 5.1H11 \| neural cell adhesion molecule 1 \| neural cell adhesion molecule \| NCAM \| NCAM-1 \| N-CAM-1
Grade	Animal Free, Azide Free, Carrier Free
Product Description	Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: Neural cell adhesion molecule 1 (NCAM-1) is a multifunctional member of the Ig superfamily. It belongs to a family of membrane-bound glycoproteins that are involved in Ca++ independent cell matrix and homophilic or heterophilic cell-cell interactions. NCAM-1 specifically binds to heparan sulfate proteoglycans, the extracellular matrix protein agrin, and several chondroitin sulfate proteoglycans that include neurocan and phosphocan. There are three main forms of human NCAM-1 that arise by alternate splicing. These are designated NCAM-120/NCAM-1 (761 amino acids [aa]), NCAM‑140 (848 aa), and NCAM-180 (1120 aa). NCAM-120 is GPI-linked, while NCAM‑140 and NCAM-180 are type I transmembrane glycoproteins. Additional alternate splicing adds considerable diversity to all three forms, and extracellular proteolytic processing is possible for NCAM-180. NCAM-1 is synthesized as a 761 aa preproprecursor that contains a 19 aa signal sequence, a 722 aa GPI-linked mature region, and a 20 aa C-terminal prosegment. The molecule contains five C-2 type Ig-like domains and two fibronectin type-III domains. Human to mouse, NCAM-1 is 93% aa identical. NCAM-1 appears to be highly sialylated. The polysialyation of NCAM-1 reduces its adhesive property and increases its neurite outgrowth promoting features. NCAM-1 in the adult brain shows a decline of sialylation relative to earlier developmental periods. In regions that retain a high degree of neuronal plasticity, however, the adult brain continues to express polysialylation-NCAM-1, suggesting sialylation of NCAM-1 is involved in regenerative processes and synaptic plasticity.
Specifications & Purity	Animal Free, Carrier Free, Azide Free, ≥90%(SDS-PAGE)
Bioactivity	Testing in progress
Endotoxin Concentration	<1.0 EU/μg
Expression System	CHO
Amino Acids	20-603 aa
Sequence	LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFHHHHHH
Protein Tag	C-His
Accession #	P13591
Predicted molecular weight	65.7 kDa
SDS-PAGE	105.8 kDa, under reducing conditions; 94.9 kDa, under non-reducing conditions.

Storage and Shipping

Shape	Lyophilized
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -20°C stable up to 1 year. Avoid freeze/thaw cycle.

Images

SDS-PAGE: Recombinant Human NCAM-1/CD56 Protein (rp175917)

Recombinant Human NCAM-1/CD56 Protein (rp175917) - SDS-PAGE
Recombinant Human NCAM-1/CD56 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 105.8 kDa under reducing conditions, showing a band at 94.9 kDa under non-reducing conditions.

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ23F1101868	Certificate of Analysis	Dec 13, 2023	rp175917
ZJ23R1100169	Certificate of Analysis	Nov 28, 2023	rp175917

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