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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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rp184044-10μg
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10μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$159.90
|
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rp184044-50μg
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50μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$459.90
|
|
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rp184044-100μg
|
100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$729.90
|
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rp184044-1mg
|
1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$4,719.90
|
|
Animal Free, ≥95% (SDS-PAGE), Active, HEK293, C-His, 1-232 aa
| Product Name | Recombinant Human IL-4R alpha Protein |
|---|---|
| Synonyms | CD124 | IL 4R alpha | IL-4 receptor subunit alpha | IL-4-binding protein | IL-4R subunit alpha | IL-4R-alpha | IL-4RA | IL4-BP | Il4r | IL4R nirs variant 1 | IL4RA | IL4RA_HUMAN | Interleukin 4 receptor | Interleukin 4 receptor alpha chain | sIL4Ralpha/pr |
| Grade | ActiBioPure™, Animal Free, Bioactive, Carrier Free, High Performance |
| Specifications & Purity | ActiBioPure™, Bioactive, Animal Free, Carrier Free, High Performance, ≥95%(SDS-PAGE) |
| Biochemical and Physiological Mechanisms | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production |
| Bioactivity | Measured by its ability to inhibit IL-4 induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 42.55 ng/mL in the presence of 20.0 ng/mL of Recombinant Human IL-4 Protein (rp147593). |
| Endotoxin Concentration | <1.0 EU/μg |
| Amino Acids | 1-232 aa |
| Sequence | MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHHHHHHH |
| Accession # | P24394 |
| Predicted molecular weight | 24.6 kDa |
| SDS-PAGE | 38.1-53.0 kDa, under reducing conditions; 38.1-53.0 kDa, under non-reducing conditions. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
|---|---|
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -20°C for 1 year. Avoid freeze/thaw cycle. |
Recombinant Human IL-4R alpha Protein (rp184044) - Protein Bioactivity
Measured by its ability to inhibit IL-4 induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 42.55 ng/mL in the presence of 20.0 ng/mL of Recombinant Human IL-4 Protein (rp147593).
Recombinant Human IL-4R alpha Protein (rp184044) - SDS-PAGE
3 μg/lane of Recombinant Human IL-4R alpha Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 38.1-53.0 kDa.