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Raphin 1 - ≥98%(HPLC), high purity , CAS No.2022961-17-5

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
R287653
Grouped product items
SKU Size
Availability
 Price Qty
R287653-5mg
5mg
3
$95.90
R287653-10mg
10mg
3
$147.90
R287653-25mg
25mg
2
$331.90
R287653-50mg
50mg
2
$614.90
R287653-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,106.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1 and brain penetrant

View related series
Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) Phosphatase (222)

Basic Description

Synonyms 2-(2,3-Dichlorobenzylidene)hydrazine-1-carboximidamide | BDBM50545524 | 3-[(2,3-DICHLOROPHENYL)METHYLENE]CARBAZAMIDINE | EN300-25957086 | N-[(E)-[(2,3-dichlorophenyl)methylidene]amino]guanidine | Pyridine, 3-(2-pyrrolidinyl)-,(S)- | (E)-2-(2,3-Dichloroben
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd= 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesisin vitro. Induces transient reduction in protein s
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Application

Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Halobenzenes
Intermediate Tree Nodes Chlorobenzenes
Direct Parent Dichlorobenzenes
Alternative Parents Aryl chlorides  Guanidines  Organopnictogen compounds  Organochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents 1,2-dichlorobenzene - Aryl halide - Aryl chloride - Guanidine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
External Descriptors Not available

Associated Targets(Human)

PPP1R15A Tchem Protein phosphatase 1 regulatory subunit 15A (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PPP1R15B Tchem Protein phosphatase 1 regulatory subunit 15B (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MELK Tchem Maternal embryonic leucine zipper kinase (3491 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CGA Tbio Glycoprotein hormones alpha chain (29278 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PPP1R15A Tchem Protein phosphatase 1 regulatory subunit 15A (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764818
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764818
IUPAC Name 2-[(E)-(2,3-dichlorophenyl)methylideneamino]guanidine
INCHI InChI=1S/C8H8Cl2N4/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+
InChIKey WLTSTDGGFCQWTK-YIXHJXPBSA-N
Smiles C1=CC(=C(C(=C1)Cl)Cl)C=NN=C(N)N
Isomeric SMILES C1=CC(=C(C(=C1)Cl)Cl)/C=N/N=C(N)N
PubChem CID 9560222
Molecular Weight 231.08

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
A2208409 Certificate of Analysis Oct 10, 2024 R287653
A2208415 Certificate of Analysis Oct 10, 2024 R287653
A2208430 Certificate of Analysis Oct 10, 2024 R287653
A2208431 Certificate of Analysis Oct 10, 2024 R287653
A2208458 Certificate of Analysis Oct 10, 2024 R287653

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 23.11, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 11.55, Max Conc. mM: 50
Molecular Weight 231.080 g/mol
XLogP3 1.700
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 2
Exact Mass 230.013 Da
Monoisotopic Mass 230.013 Da
Topological Polar Surface Area 76.800 Ų
Heavy Atom Count 14
Formal Charge 0
Complexity 237.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Solution Calculators

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