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(R)-Lisofylline - 98%, high purity , CAS No.100324-81-0

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 100324-81-0
Molecular Weight: 280.32
PubChem CID: 501254
PubChem SID: 504758954

In stock

Item Number

R341807

Grouped product items
SKU	Size	Availability	Price
R341807-2mg	2mg	3	$332.90
R341807-5mg	5mg	3	$692.90
R341807-10mg	10mg	3	$1,137.90
R341807-25mg	25mg	3	$2,276.90
R341807-50mg	50mg	3	$3,612.90

an immunomodulator and metabolite of Pentoxifyline, it inhibits phosphatidic acid production

View related series

JAK/STAT Signaling (507) STAT (139) Stem Cell/Wnt (1019)

Basic Description

Synonyms	(-)-lisofylline \| ProTec (TN) \| 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione \| 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione \| 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-purine-2,6-dione \| GTPL9225 \| LISOFYL
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Product Description	(R)-Lisofylline is an immunomodulator and a major metabolite of Pentoxifylline and Methylxanthine. (R)-Lisofylline inhibits production of phosphatidic acid during the inflammatory response.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Imidazopyrimidines
    - Subclass Purines and purine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Imidazopyrimidines
Subclass	Purines and purine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Xanthines
Alternative Parents	6-oxopurines Alkaloids and derivatives Pyrimidones N-substituted imidazoles Vinylogous amides Heteroaromatic compounds Ureas Secondary alcohols Lactams Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Xanthine - 6-oxopurine - Purinone - Alkaloid or derivatives - Pyrimidone - N-substituted imidazole - Pyrimidine - Azole - Imidazole - Heteroaromatic compound - Vinylogous amide - Secondary alcohol - Lactam - Urea - Azacycle - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Alcohol - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

pKa	pKₐ: 0.51 (Predicted)

Associated Targets(Human)

ALB Tchem Serum albumin (2651 Activities)

Discover Target: ALB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

INS1 (2867 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504758954
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504758954
IUPAC Name	1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione
INCHI	InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m1/s1
InChIKey	NSMXQKNUPPXBRG-SECBINFHSA-N
Smiles	CC(CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C)O
Isomeric SMILES	C[C@H](CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C)O
Molecular Weight	280.32
Reaxy-Rn	622590
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=622590&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
C2301302	Certificate of Analysis	Sep 08, 2022	R341807
C2505281	Certificate of Analysis	Sep 08, 2022	R341807
C2301317	Certificate of Analysis	Sep 08, 2022	R341807
C2301297	Certificate of Analysis	Sep 08, 2022	R341807
C2301298	Certificate of Analysis	Sep 08, 2022	R341807
C2301299	Certificate of Analysis	Sep 08, 2022	R341807

Chemical and Physical Properties

Solubility	Soluble in ethanol (~25 mg/ml), DMSO (~20 mg/ml), DMF (~15 mg/ml), chloroform, and methanol.
Sensitivity	Moisture sensitive
Refractive Index	n20D1.62 (Predicted)
Specific Rotation[α]	α20/D -6.26°, c = 1 in methanol
Boil Point(°C)	511.2° C at 760 mmHg (Predicted)
Melt Point(°C)	105-107° C
Molecular Weight	280.320 g/mol
XLogP3	0.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	280.154 Da
Monoisotopic Mass	280.154 Da
Topological Polar Surface Area	78.700 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	390.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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(R)-Lisofylline - 98%, high purity , CAS No.100324-81-0

Basic Description

Taxonomic Classification

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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