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R 59-022 hydrochloride - 98%, high purity , CAS No.93076-98-3

COA

Grade & Purity:

≥98%

Cas Number: 93076-98-3
Molecular Weight: 496.04

In stock

Item Number

R649075

Grouped product items
SKU	Size	Availability	Price
R649075-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$110.90
R649075-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$180.90
R649075-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$360.90
R649075-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$580.90

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Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor ( IC 50 : 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC) . R 59-022 hydrochloride p
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor ( IC 50 : 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils. In Vitro R 59-022 (10 μM, 1 min) hydrochloride potentiates aggregation, but not shape change induced by sub-maximal concentrations of thrombin. R 59-022 (30 μM, 0-60 min) hydrochloride increases release of Noradrenaline in chromaffin cells. R 59-022 (40 μM, 30 min) hydrochloride activates PKC in HeLa and U87 cells . R 59-022 (0-10 μM, 4 h) hydrochloride blocks EBOV GP-mediated entry into Vero cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis Cell Line: HeLa cells Concentration: 40 uM Incubation Time: 30 min Result: Increased the phosphorylation of PKC downstream targets by about 2.5-fold. In Vivo R 59-022 (2 mg/kg, i.p., 12 days) hydrochloride significantly increases median survival in SCID mice implanted with U87 GBM cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: SCID mice implanted with U87 GBM cells Dosage: 10 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Increased median survival and decreased tumor volume. Form:Solid

Names and Identifiers

Smiles	O=C1C(CCN(CC/2)CCC2=C(C3=CC=CC=C3)/C4=CC=C(F)C=C4)=C(C)N=C5N1C=CS5.[H]Cl
Molecular Weight	496.04

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