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R-486, Antagonist of NK 1 receptor, CAS No.132041-95-3, Antagonist of NK 1 receptor

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Item Number
rp174871
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rp174871-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
rp174871-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,334.90

Basic Description

Product Name R-486, Antagonist of NK 1 receptor, CAS No.132041-95-3
Synonyms [Trp⁷,β-Ala⁸]neurokinin A(4-10);MEN 10295;R 486;R486
Grade Moligand™
Specifications & Purity Moligand™
Action Type ANTAGONIST
Mechanism of action Antagonist of NK 1 receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Peptidomimetics
Subclass Hybrid peptides
Intermediate Tree Nodes Not available
Direct Parent Hybrid peptides
Alternative Parents Dipeptides  Phenylalanine and derivatives  Methionine and derivatives  Leucine and derivatives  Aspartic acid and derivatives  N-acyl-alpha amino acids and derivatives  Tryptamines and derivatives  Serine and derivatives  Alpha amino acid amides  Beta amino acids and derivatives  Amphetamines and derivatives  3-alkylindoles  Substituted pyrroles  N-acyl amines  Heteroaromatic compounds  Secondary carboxylic acid amides  Primary carboxylic acid amides  Amino acids  Sulfenyl compounds  Monocarboxylic acids and derivatives  Dialkylthioethers  Carboxylic acids  Azacyclic compounds  Primary alcohols  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Hybrid peptide - Alpha-dipeptide - Phenylalanine or derivatives - Leucine or derivatives - Aspartic acid or derivatives - Methionine or derivatives - N-acyl-alpha amino acid or derivatives - Serine or derivatives - Triptan - Alpha-amino acid amide - Beta amino acid or derivatives - 3-alkylindole - Amphetamine or derivatives - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Indole or derivatives - Indole - Fatty acyl - Benzenoid - Substituted pyrrole - N-acyl-amine - Fatty amide - Monocyclic benzene moiety - Heteroaromatic compound - Pyrrole - Amino acid - Secondary carboxylic acid amide - Primary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Azacycle - Organoheterocyclic compound - Dialkylthioether - Sulfenyl compound - Thioether - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Primary alcohol - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Amine - Alcohol - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
External Descriptors Not available

Associated Targets(Human)

TACR1 Tclin Substance-P receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

CAS 132041-95-3

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names [Trp⁷,β-Ala⁸]neurokinin A(4-10);MEN 10295;R 486;R486
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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