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Quisqualic acid - ≥99%, high purity , CAS No.52809-07-1, Inhibitor of Cystine/glutamate transporter;Agonist of mGlu 1 receptor;Agonist of mGlu 5 receptor

COA

Grade & Purity:

Moligand™

≥99%

Cas Number: 52809-07-1
Molecular Weight: 189.13
Beilstein Registry Number: 1078734
EC Number: 637-070-2
PubChem CID: 40539

In stock

Item Number

Q276562

Grouped product items
SKU	Size	Availability	Price	Qty
Q276562-20mM-ml	20mM/ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$100.90

Group I mGlu agonist. AMPA agonist. 1 ml water soluble pack.

View related series

Class C GPCR (248) Cystine/glutamate transporter Inhibitor (1) GPCR/G Protein (3172) Ion channel (2197) Membrane Transporter/Ion Channel (1822) mGlu1 receptor Agonist (8) mGlu5 receptor Agonist (12) mGluR (176) Neuronal Signaling (3320)

Basic Description

Synonyms	NCGC00024489-07 \| NCGC00261724-01 \| HMS2233G05 \| (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID \| MS-23020 \| HMS3411A13 \| L-quisqualic-acid \| [3H]quisqualate \| 1mm7 \| (L)-(+)-?-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid \| 8O
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Potent group I mGlu agonist and AMPA receptor agonist. Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	AGONIST, INHIBITOR
Mechanism of action	Inhibitor of Cystine/glutamate transporter;Agonist of mGlu 1 receptor;Agonist of mGlu 5 receptor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acids
        Level8 L-alpha-amino acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct Parent	L-alpha-amino acids
Alternative Parents	Heteroaromatic compounds 1,2,4-oxadiazoles Amino acids Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	L-alpha-amino acid - 1,2,4-oxadiazole - Azole - Oxadiazole - Heteroaromatic compound - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Azacycle - Oxacycle - Primary amine - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Amine - Primary aliphatic amine - Organic nitrogen compound - Organic oxygen compound - Carbonyl group - Organic oxide - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors	non-proteinogenic alpha-amino acid
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC7A11 Tchem Cystine/glutamate transporter (1 Activities)

Discover Target: SLC7A11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM1 Tchem Metabotropic glutamate receptor 1 (0 Activities)

Discover Target: GRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 (2 Activities)

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
INCHI	InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChIKey	ASNFTDCKZKHJSW-REOHCLBHSA-N
Smiles	C(C(C(=O)O)N)N1C(=O)NC(=O)O1
Isomeric SMILES	C([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1
WGK Germany	3
Alternate CAS	52809-07-1
PubChem CID	40539
MeSH Entry Terms	Quisqualate;Quisqualic Acid
Molecular Weight	189.13
Beilstein	1078734

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Soluble in 1ml of water to give specified mM/ml concentration
Molecular Weight	189.130 g/mol
XLogP3	-3.900
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	189.039 Da
Monoisotopic Mass	189.039 Da
Topological Polar Surface Area	122.000 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	265.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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