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Quisinostat (JNJ-26481585) 2HCl - 98%, high purity , CAS No.875320-31-3

COA

Grade & Purity:

≥98%

Cas Number: 875320-31-3
Molecular Weight: 467.39
PubChem CID: 122129987
PubChem SID: 504772960

In stock

Item Number

Q412686

Grouped product items
SKU	Size	Availability	Price
Q412686-5mg	5mg	3	$155.90
Q412686-10mg	10mg	3	$273.90
Q412686-50mg	50mg	3	$547.90

HDAC8 Selective Inhibitors

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Basic Description

Synonyms	N-hydroxy-2-(4-(((1-methyl-1H-indol-3-yl)methylamino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 an
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Quisinostat (JNJ-26481585) 2HCl is a novel second-generationHDACinhibitor with highest potency for HDAC1 withIC50of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2. Targets HDAC1 (Cell-free assay); HDAC2 (Cell-free assay); HDAC11 (Cell-free assay); HDAC10 (Cell-free assay); HDAC4 (Cell-free assay) 97,0.11 nM; 0.33 nM; 0.37 nM; 0.46 nM; 0.64 nM In vitro JNJ-26481585 exhibits broad spectrum antiproliferative activity in solid and hematologic cancer cell lines, such as all lung, breast, colon, prostate, brain, and ovarian tumor cell lines, with IC50 ranging from 3.1-246 nM, which is more potent than vorinostat, R306465, panobinostat, CRA-24781, or mocetinostat in various human cancer cell lines tested. A recent study shows that JNJ-26481585 promotes myeloma cell death at low nanomolar concentrations by resulting in Mcl-1 depletion and Hsp72 induction. In vivo In an HDAC1-responsive A2780 ovarian tumor screening model, JNJ-26481585 dosing at its maximal tolerated dose (10 mg/kg i.p. and 40 mg/kg p.o.) for 3 days leads to an HDAC1-regulated fluorescence , which predicts tumor growth inhibition. Furthermore, JNJ-26481585 also shows more potent inhibitory effects on the growth of C170HM2 colorectal liver metastases than 5-fluorouracil/Leucovorin. Cell Research(from reference) Cell lines：NCL-H2106, Colo699 and LNCAP cells Concentrations：0-300 nM Incubation Time：24 hours

Product Properties

ALogP	2.749
HBD Count	2
Rotatable Bond	6

Names and Identifiers

Pubchem Sid	504772960
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772960
IUPAC Name	N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide;dihydrochloride
INCHI	InChI=1S/C21H26N6O2.2ClH/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29;;/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28);2*1H
InChIKey	NRUIZESXVMJDKR-UHFFFAOYSA-N
Smiles	CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl.Cl
PubChem CID	122129987
Molecular Weight	467.39

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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3 results found

Lot Number	Certificate Type	Date	Item
G2203405	Certificate of Analysis	Apr 07, 2024	Q412686
G2203406	Certificate of Analysis	Apr 07, 2024	Q412686
G2203407	Certificate of Analysis	Apr 07, 2024	Q412686

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 79 mg/mL (169.02 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	79
DMSO(mM) Max Solubility	169.0237275
Water(mg / mL) Max Solubility	＜1
Molecular Weight	467.400 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	466.165 Da
Monoisotopic Mass	466.165 Da
Topological Polar Surface Area	95.300 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	533.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

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