Basic Description

Synonyms	AC-6224 \| HY-B0433A \| S2502 \| FEMA NO. 2976, DIHYDRATE- \| Quinine.HCl.dihydrate \| (-)-Quinine hydrochloride dihydrate \| (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrate;hydrochloride \| 711S8Y0T33 \| QUININ
Specifications & Purity	≥90%
Product Description	General Description Quinine monohydrochloride dihydrate is commonly used as a standard for bitterness in sensory evaluation experiments of food samples. Other Notes Remainder hydroquinine hydrochloride dihydrate

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Class Cinchona alkaloids

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Class	Cinchona alkaloids
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Cinchona alkaloids
Alternative Parents	4-quinolinemethanols Quinuclidines Anisoles Alkyl aryl ethers Aralkylamines Pyridines and derivatives Piperidines Heteroaromatic compounds Trialkylamines 1,2-aminoalcohols Secondary alcohols Azacyclic compounds Hydrochlorides Hydrocarbon derivatives Aromatic alcohols Organic oxides Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Cinchonan-skeleton - 4-quinolinemethanol - Quinoline - Anisole - Quinuclidine - Alkyl aryl ether - Aralkylamine - Piperidine - Pyridine - Benzenoid - Heteroaromatic compound - 1,2-aminoalcohol - Secondary alcohol - Tertiary aliphatic amine - Tertiary amine - Ether - Azacycle - Organoheterocyclic compound - Alcohol - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Amine - Hydrochloride - Organic oxygen compound - Aromatic alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as cinchona alkaloids. These are alkaloids structurally characterized by the presence of the cinchonan skeleton, which consists of a quinoline linked to an azabicyclo[2.2.2]octane moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrate;hydrochloride
INCHI	InChI=1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1
InChIKey	MPQKYZPYCSTMEI-FLZPLBAKSA-N
Smiles	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.Cl
Isomeric SMILES	COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.O.O.Cl
WGK Germany	3
RTECS	VA7700000
PubChem CID	16211283
Molecular Weight	396.91
Beilstein	6112655
Reaxy-Rn	8370495

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Specific Rotation[α]	-245 to -255 deg(C=2, 0.1mol/l HCl(calcd.on dried substance)
Melt Point(°C)	160℃
Molecular Weight	396.900 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	396.182 Da
Monoisotopic Mass	396.182 Da
Topological Polar Surface Area	47.600 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	457.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	4

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Lancheng Wang, Huimin Zhou, Kun Yan, Peng Xu, Bin Di, Chi Hu, Mengxiang Su. (2021) Using dual exonucleases to finely distinguish structural adjustment of aptamers for small-molecule detection. RSC Advances, 11 (52): (32898-32903).
2. Jieyao Yu, Yan Liu, Shaorong Zhang, Liyong Luo, Liang Zeng. (2021) Effect of brewing conditions on phytochemicals and sensory profiles of black tea infusions: A primary study on the effects of geraniol and β-ionone on taste perception of black tea infusions. FOOD CHEMISTRY, 354 (129504).
3. Xuan Luo, Susu Cui, Weiwei Yang, Yongsheng Yu. (2025) An electrochemical quinine detection approach based on small molecule promoted split aptamer click ligation reaction. TALANTA, 292 (127916).

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SKU	Size	Availability	Price	Qty
Q433097-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$106.90
Q433097-50g	50g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$430.90

Quinine monohydrochloride dihydrate - 90%, high purity , CAS No.6119-47-7