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Basic Description
| Synonyms | PYRIDOXAL HYDROCHLORIDE | 65-22-5 | Pyridoxal HCl | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride | 2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine hydrochloride | MFCD00012809 | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde, hydro |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Pyridoxal hydrochloride interacts with cysteine of cathepsins and inhibits their activity. It elicits protective function in cornu Ammonis (CA) 1 neurons during ischemia.Pyridoxal hydrochloride is an endogenous metabolite. |
| Storage Temp | Store at -80°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
Pyridoxal hydrochloride is used in labeling of amino acids for their detection. It finds application in neurotransmitters, sphingolipids and aminolevulinic acid. It is also used as a nutritional agent. It is also applied in research studies like biochemical, drugs and in media supplements.
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Taxonomic Classification
Taxonomy Tree
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Kingdom
Organic compounds
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Superclass
Organoheterocyclic compounds
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Class
Pyridines and derivatives
- Subclass Pyridine carboxaldehydes
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Class
Pyridines and derivatives
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Superclass
Organoheterocyclic compounds
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Pyridines and derivatives |
| Subclass | Pyridine carboxaldehydes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Pyridoxals and derivatives |
| Alternative Parents | Methylpyridines Hydroxypyridines Aryl-aldehydes Vinylogous acids Heteroaromatic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Aromatic alcohols |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Pyridoxal - Aryl-aldehyde - Methylpyridine - Hydroxypyridine - Vinylogous acid - Heteroaromatic compound - Azacycle - Alcohol - Hydrocarbon derivative - Organic oxide - Hydrochloride - Organopnictogen compound - Organic oxygen compound - Aromatic alcohol - Organic nitrogen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Aldehyde - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as pyridoxals and derivatives. These are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2,3,4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively. |
| External Descriptors | Not available |
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Associated Targets(Human)
CAD
Tchem
Dihydroorotase (27 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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TRIM33
Tchem
E3 ubiquitin-protein ligase TRIM33 (162 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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TRIM24
Tchem
Transcription intermediary factor 1-alpha (2087 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Associated Targets(non-human)
rep
Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde;hydrochloride |
|---|---|
| INCHI | InChI=1S/C8H9NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,4,10,12H,3H2,1H3;1H |
| InChIKey | FCHXJFJNDJXENQ-UHFFFAOYSA-N |
| Smiles | CC1=NC=C(C(=C1O)C=O)CO.Cl |
| Isomeric SMILES | CC1=NC=C(C(=C1O)C=O)CO.Cl |
| WGK Germany | 2 |
| RTECS | UV1225000 |
| Molecular Weight | 203.62 |
| Beilstein | 3656994 |
| Reaxy-Rn | 3656994 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3656994&ln= |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Sensitivity | Light Sensitive,Air Sensitive |
|---|---|
| Melt Point(°C) | 172°C |
| Molecular Weight | 203.620 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 203.035 Da |
| Monoisotopic Mass | 203.035 Da |
| Topological Polar Surface Area | 70.400 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 162.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
Citations of This Product
| 1. Deng Hao-Hua, Yang Hui-Jing, Huang Kai-Yuan, Zheng Yi-Jing, Xu Ying-Ying, Peng Hua-Ping, Liu Yin-Huan, Chen Wei, Hong Guo-Lin. (2022) Antenna effect of pyridoxal phosphate on the fluorescence of mitoxantrone-silicon nanoparticles and its application in alkaline phosphatase assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (17): (4877-4884). |
| 2. Hao-Hua Deng, Kai-Yuan Huang, Quan-Hui Fang, Ya-Ping Lv, Shao-Bin He, Hua-Ping Peng, Xing-Hua Xia, Wei Chen. (2020) Schiff base and Lewis acid-base interaction-regulated aggregation/dispersion of gold nanoparticles for colorimetric recognition of rare-earth Sc3+ ions. SENSORS AND ACTUATORS B-CHEMICAL, 311 (127925). |
| 3. Q. Huang, Y. T. Chen, Y. W. Ren, Z. Y. Wang, Y. X. Zhu, Y. Zhang. (2018) A rapid and naked-eye visible rhodamine 6G-based chemosensor for sensitive detection of copper(II) ions in aqueous solution. Analytical Methods, 10 (47): (5731-5737). |
| 4. Su Yao, Gongke Li, Yanqing Liu, Shoulian Wei, Hongwu Wang, Xiqing Huang, Zetao Luo. (2018) Electrochemical detection of pyridoxal using a sonoelectrochemical prepared highly-oxidized carbon nanosheets modified electrode. SENSORS AND ACTUATORS B-CHEMICAL, 274 (324). |
| 5. Qi Huang, Qingyou Zhang, Enze Wang, Yanmei Zhou, Han Qiao, Lanfang Pang, Fang Yu. (2016) A new “off–on” fluorescent probe for Al3+ in aqueous solution based on rhodamine B and its application to bioimaging. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 152 (70). |
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