This is a demo store. No orders will be fulfilled.

 
Call +1 (833) 552-7181 or Contact us
Toggle Nav
My Cart
Search
Advanced Search
Menu
Account
Settings
྾
main product photo

Pyridoxal 5′-phosphate hydrate - ≥98%, high purity , CAS No.853645-22-4

18 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
P136795
Grouped product items
SKU Size
Availability
 Price Qty
P136795-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$14.90
P136795-5g
5g
2
$42.90
P136795-25g
25g
3
$133.90
P136795-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$339.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
MAPK/ERK Pathway (546) Metabolic Enzyme/Protease (4860) Metabolite (5307)

Basic Description

Synonyms Vitazechs | FT-0631236 | P5P | P-5'-P | Pyromijin | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate | CCG-266929 | EX-A980 | MC-1 | Pyridoxal 5/'-phosphate (hydrate) | SGCUT00188 | VITAMIN B6 (PYRIDOXAL 5-PHOSPHATE) | 3-hydroxy-2-methyl
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Pyridoxal 5′-phosphate is used as a cofactor for a wide range of enzymes including mitochondrial cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and d-serine dehydratase. PLP is used in the studies of PLP-dependent e
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

 Product Description：

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.


 Product Application：

Pyridoxal 5′-phosphate hydrate has also been used: as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)； in D-amino acid transaminase reaction(10)；as a cofactor for L-glutamic acid decarboxylase

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Pyridines and derivatives
Subclass Pyridine carboxaldehydes
Intermediate Tree Nodes Not available
Direct Parent Pyridoxals and derivatives
Alternative Parents Monoalkyl phosphates  Methylpyridines  Hydroxypyridines  Aryl-aldehydes  Vinylogous acids  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Pyridoxal - Aryl-aldehyde - Monoalkyl phosphate - Hydroxypyridine - Methylpyridine - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Vinylogous acid - Heteroaromatic compound - Azacycle - Organopnictogen compound - Aldehyde - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as pyridoxals and derivatives. These are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2,3,4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively.
External Descriptors monohydroxypyridine - pyridinecarbaldehyde - methylpyridines - vitamin B6 phosphate

Associated Targets(Human)

P2RX1 Tchem P2X purinoceptor 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RX4 Tchem P2X purinoceptor 4 (516 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RX1 Tchem P2X purinoceptor 1 (328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAD Tchem Dihydroorotase (27 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (330 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

P2rx2 P2X purinoceptor 2 (106 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2rx3 P2X purinoceptor 3 (632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trans-sialidase (51 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
INCHI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N
Smiles CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
Isomeric SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
WGK Germany 3
Molecular Weight 247.14 (anhydrous basis)
Beilstein 234749
Reaxy-Rn 234749
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=234749&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number Certificate Type Date Item
F2524735 Certificate of Analysis Jun 12, 2025 P136795
F2520614 Certificate of Analysis Jun 12, 2025 P136795
F2520631 Certificate of Analysis Jun 12, 2025 P136795
F2520629 Certificate of Analysis Jun 12, 2025 P136795
D2321357 Certificate of Analysis Feb 11, 2025 P136795
J2424255 Certificate of Analysis Oct 31, 2024 P136795
F2510672 Certificate of Analysis Jul 10, 2024 P136795
F2510674 Certificate of Analysis Jul 10, 2024 P136795
F2510673 Certificate of Analysis Jul 10, 2024 P136795
F2510675 Certificate of Analysis Jul 10, 2024 P136795
K2125309 Certificate of Analysis Sep 11, 2023 P136795
K2125185 Certificate of Analysis Sep 11, 2023 P136795
F1509085 Certificate of Analysis Jun 09, 2023 P136795
B2208069 Certificate of Analysis Aug 27, 2021 P136795
E2413020 Certificate of Analysis Aug 27, 2021 P136795

Show more⌵

Chemical and Physical Properties

Melt Point(°C) 140-143°C
Molecular Weight 247.140 g/mol
XLogP3 -1.100
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 4
Exact Mass 247.025 Da
Monoisotopic Mass 247.025 Da
Topological Polar Surface Area 117.000 Ų
Heavy Atom Count 16
Formal Charge 0
Complexity 292.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang.  (2023)  Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents.  MOLECULES,  28  (9): (3895). 
2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su.  (2023)  High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis.  ACS Omega,  8  (8): (8101–8109). 
3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2023)  A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity.  Catalysis Science & Technology,  13  (3): (684-693). 
4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu.  (2022)  Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment.  ADVANCED SYNTHESIS & CATALYSIS,  364  (24): (4363-4370). 
5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi.  (2022)  Visible spectrophotometric assay for characterization of ω-transaminases.  ANALYTICAL BIOCHEMISTRY,  658  (114933). 
6. Li-Chao Wang, Lian Xu, Bing-Mei Su, Xin-Qi Xu, Juan Lin.  (2022)  An Effective Chemo-Enzymatic method with An Evolved L-Threonine Aldolase for Preparing L-threo-4-Methylsulfonylphenylserine Ethyl Ester of High Optical Purity.  Molecular Catalysis,  525  (112355). 
7. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin.  (2021)  Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance.  CHEMISTRY-A EUROPEAN JOURNAL,  27  (37): (9654-9660). 
8. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai.  (2020)  Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells.  Catalysts,  10  (9): (947). 
9. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin.  (2020)  An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  CHEMICAL ENGINEERING SCIENCE,  226  (115812). 
10. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin.  (2019)  Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids.  Catalysis Science & Technology,  9  (21): (5943-5952). 
11. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng.  (2019)  Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp..  JOURNAL OF BIOTECHNOLOGY,  295  (49). 
12. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He.  (2018)  Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  102  (14): (6047-6056). 
13. Qian Wang, Xiao-Mei He, Xi Chen, Gang-Tian Zhu, Ren-Qi Wang, Yu-Qi Feng.  (2017)  Pyridoxal 5′-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides.  JOURNAL OF CHROMATOGRAPHY A,  1499  (30). 
14. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568). 
15. S. Tang, D. Huang, N. An, D. Chen, D. Zhao.  (2016)  A novel pathway for the production of H2S by DAO in rat jejunum.  NEUROGASTROENTEROLOGY AND MOTILITY,  28  (5): (687-692). 
16. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li.  (2015-11-05)  H2S, a novel gasotransmitter, involves in gastric accommodation..  Scientific reports,  5  (16086-16086). 
17. Binbin Chen, Jiahui Huang, Yingchun Liu, Lirong Yang, Qi Wang, Haoran Yu.  (2025)  Computational Study on the Catalytic Mechanism of UstD Catalyzing the Synthesis of γ-Hydroxy-α-Amino Acids.  Journal of Chemical Information and Modeling,  65  (4): (2026-2037). 
18. Ying-Ying Xu, Bin Zhang, Jie Bao.  (2025)  Production of γ-aminobutyric acid using corncob residue as carbohydrate feedstock by engineered Corynebacterium glutamicum.  BIOCHEMICAL ENGINEERING JOURNAL,  215  (109629). 

Solution Calculators

Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.