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Purpurogallin - 96%, high purity , CAS No.569-77-7

COA

Grade & Purity:

Moligand™

≥96%

Cas Number: 569-77-7
Molecular Weight: 220.17

In stock

Item Number

P649449

Grouped product items
SKU	Size	Availability	Price
P649449-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$22.90
P649449-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$45.90
P649449-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$117.90
P649449-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$236.90

Phenols Polyphenols

View related series

Amino Acid/Protein Metabolism (1836) Metabolic Enzyme/Protease (4860) Phenols Polyphenols (41) Xanthine Oxidase (24)

Basic Description

Synonyms	2,3,4,6-Tetrahydroxy-5H-benzo[7]annulen-5-one \| NCI 35676 \| NSC 35676 \| NSC 646653
Specifications & Purity	Moligand™, ≥96%
Biochemical and Physiological Mechanisms	Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC 50 of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Product Description	Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC 50 of 0.2 µM. Purpurogallin has antioxidant and anti-inflammatory effects In Vitro Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells. Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: BV2 murine microglial cells Concentration: 50 or 100 µM Incubation Time: 7 or 25 hours Result: Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression. Western Blot AnalysisCell Line: BV2 murine microglial cells Concentration: 100 µM Incubation Time: 75 minutes, 90 minutes, 120 minutes Result: Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways. In Vivo Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Fifty-four male Sprague-Dawley rats (250-350 g) with subarachnoid hemorrhage (SAH)Dosage: 100 μg/kg, 200 μg/kg, 400 μg/kg Administration: Intraperitoneal injection; for 48 or 72 hours Result: Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels. Form:Solid IC50& Target:IC50: 0.2 µM (xanthine oxidase)

Names and Identifiers

Smiles	O=C1C(O)=CC=CC2=CC(O)=C(O)C(O)=C21
Molecular Weight	220.17

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8 results found

Lot Number	Certificate Type	Date	Item
G2501638	Certificate of Analysis	Jun 10, 2025	P649449
G2501635	Certificate of Analysis	Jun 10, 2025	P649449
G2501636	Certificate of Analysis	Jun 10, 2025	P649449
G2501637	Certificate of Analysis	Jun 10, 2025	P649449
G2501639	Certificate of Analysis	Jun 10, 2025	P649449
G2501640	Certificate of Analysis	Jun 10, 2025	P649449
G2501641	Certificate of Analysis	Jun 10, 2025	P649449
G2501642	Certificate of Analysis	Jun 10, 2025	P649449

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Purpurogallin - 96%, high purity , CAS No.569-77-7

Basic Description

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

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Molarity Calculator

Dilution Calculator

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