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Purmorphamine - ≥98%, high purity , CAS No.483367-10-8, Agonist of SMO

1 Citations

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 483367-10-8
Molecular Weight: 520.62
PubChem CID: 5284329
PubChem SID: 504763480

In stock

Item Number

P126030

Grouped product items
SKU	Size	Availability	Price
P126030-5mg	5mg	2	$49.90
P126030-10mg	10mg	2	$79.90
P126030-25mg	25mg	2	$149.90
P126030-100mg	100mg	2	$339.90

Smoothened receptor agonist

View related series

Autophagy (1917) Smo (39) SMO Agonist (2) Stem Cell/Wnt (1019)

Basic Description

Synonyms	Shh Signaling Antagonist VI \| 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display os
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of SMO
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. An activator of the hedgehog (Hh) signaling pathway.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Oxazinanes
    - Subclass Morpholines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Oxazinanes
Subclass	Morpholines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylmorpholines
Alternative Parents	Diarylethers Naphthalenes 6-aminopurines Dialkylarylamines Aniline and substituted anilines Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Heteroaromatic compounds Secondary amines Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenylmorpholine - Diaryl ether - 6-aminopurine - Naphthalene - Imidazopyrimidine - Purine - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Aminopyrimidine - Imidolactam - Monocyclic benzene moiety - N-substituted imidazole - Pyrimidine - Benzenoid - Heteroaromatic compound - Azole - Imidazole - Tertiary amine - Oxacycle - Secondary amine - Azacycle - Dialkyl ether - Ether - Organooxygen compound - Organic oxygen compound - Organopnictogen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond.
External Descriptors	purines - morpholines
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SMO Tclin Smoothened homolog (0 Activities)

Discover Target: SMO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMO Tclin Smoothened homolog (1371 Activities)

Discover Target: SMO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

C3H 10T1/2 (488 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Shh Sonic hedgehog protein (356 Activities)

Discover Target: Shh

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504763480
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504763480
IUPAC Name	9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine
INCHI	InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChIKey	FYBHCRQFSFYWPY-UHFFFAOYSA-N
Smiles	C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7
Isomeric SMILES	C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7
WGK Germany	3
Molecular Weight	520.62
Reaxy-Rn	10500685
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10500685&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
L2402563	Certificate of Analysis	Aug 26, 2024	P126030
L2402550	Certificate of Analysis	Aug 26, 2024	P126030
L2402551	Certificate of Analysis	Aug 26, 2024	P126030
L2402562	Certificate of Analysis	Aug 26, 2024	P126030
A2206292	Certificate of Analysis	Oct 23, 2023	P126030
D1523032	Certificate of Analysis	Jan 05, 2023	P126030

Chemical and Physical Properties

Solubility	Soluble in DMSO (10 mM), DMF (~20 mg/ml), DMF:PBS(pH 7.2) (1:1) (~0.25 mg/ml), and chloroform.
Molecular Weight	520.600 g/mol
XLogP3	6.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	520.259 Da
Monoisotopic Mass	520.259 Da
Topological Polar Surface Area	77.300 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	768.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Li Li, Qiuhong Li, Lei Wei, Zhongfu Wang, Wei Ma, Fangying Liu, Yanhua Shen, Shanfang Zhang, Xiulian Zhang, Huiping Li, Yechang Qian. (2019) Dexamethasone combined with berberine is an effective therapy for bleomycin‑induced pulmonary fibrosis in rats. Experimental and Therapeutic Medicine, 18 (4): (2385-2392).

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