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PTC 209 - ≥98%(HPLC), high purity , CAS No.315704-66-6

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 315704-66-6
Molecular Weight: 495.19
PubChem CID: 1117196
PubChem SID: 504760391

In stock

Item Number

P287327

Grouped product items
SKU	Size	Availability	Price
P287327-5mg	5mg	3	$146.90
P287327-10mg	10mg	2	$226.90
P287327-25mg	25mg	2	$508.90
P287327-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$950.90

Bmi-1 inhibitor; antitumor

View related series

Autophagy (1917)

Basic Description

Synonyms	FT-0700288 \| Oprea1_578634 \| EN300-175183 \| PTC209 \| PTC-209 \| AS-16950 \| s7372 \| AC-32640 \| BCP09028 \| HY-15888 \| N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine \| C17H13Br2N5OS \| HMS3653M18 \| PTC 209 \| Oprea1_5891
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Bmi-1 inhibitor (IC50~ 0.5μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumorsin vivo.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	product description： PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Imidazo[1,2-a]pyrimidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Imidazo[1,2-a]pyrimidines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Imidazo[1,2-a]pyrimidines
Alternative Parents	Methoxyanilines Phenoxy compounds Methoxybenzenes Anisoles 2,4-disubstituted thiazoles Alkyl aryl ethers Bromobenzenes Pyrimidines and pyrimidine derivatives 2-amino-1,3-thiazoles N-substituted imidazoles Aryl bromides Heteroaromatic compounds Secondary amines Azacyclic compounds Hydrocarbon derivatives Organobromides Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Imidazo[1,2-a]pyrimidine - Methoxyaniline - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Aniline or substituted anilines - 2,4-disubstituted 1,3-thiazole - Alkyl aryl ether - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Monocyclic benzene moiety - N-substituted imidazole - Pyrimidine - Benzenoid - 1,3-thiazol-2-amine - Thiazole - Azole - Imidazole - Heteroaromatic compound - Secondary amine - Azacycle - Ether - Organic oxygen compound - Hydrocarbon derivative - Amine - Organopnictogen compound - Organooxygen compound - Organohalogen compound - Organobromide - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as imidazo[1,2-a]pyrimidines. These are aromatic heteropolycyclic compounds containing an imidazole ring fused to and sharing one nitrogen with a pyrimidine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HCT-8 (3484 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-29 (80576 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BMI1 Tbio Polycomb complex protein BMI-1 (42 Activities)

Discover Target: BMI1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504760391
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504760391
IUPAC Name	N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-1,3-thiazol-2-amine
INCHI	InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H,1-2H3,(H,22,23)
InChIKey	XVOOCQSWCCRVDY-UHFFFAOYSA-N
Smiles	CC1=C(N2C=CC=NC2=N1)C3=CSC(=N3)NC4=C(C=C(C=C4Br)OC)Br
Isomeric SMILES	CC1=C(N2C=CC=NC2=N1)C3=CSC(=N3)NC4=C(C=C(C=C4Br)OC)Br
PubChem CID	1117196
Molecular Weight	495.19

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
J2129911	Certificate of Analysis	Aug 14, 2024	P287327
J2129944	Certificate of Analysis	Aug 14, 2024	P287327
J2129945	Certificate of Analysis	Aug 14, 2024	P287327
J2129946	Certificate of Analysis	Aug 14, 2024	P287327

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 49.52, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.9, Max Conc. mM: 20
Molecular Weight	495.200 g/mol
XLogP3	5.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	494.919 Da
Monoisotopic Mass	492.921 Da
Topological Polar Surface Area	92.600 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	480.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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PTC 209 - ≥98%(HPLC), high purity , CAS No.315704-66-6

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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