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PS 48 - 98% , high purity , CAS No.1180676-32-7

1 Citations

COA

Grade & Purity:

≥98%

Cas Number: 1180676-32-7
Molecular Weight: 286.76
PubChem CID: 44141940
PubChem SID: 504770282

In stock

Item Number

P343334

Grouped product items
SKU	Size	Availability	Price
P343334-10mg	10mg	3	$125.90
P343334-25mg	25mg	3	$407.90
P343334-50mg	50mg	2	$733.90
P343334-100mg	100mg	2	$1,320.90

a phosphoinositide-dependent protein kinase-1 (PDK1) activator

Basic Description

Synonyms	(Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
Specifications & Purity	≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PS 48 has been shown to be a PKB Kinase (phosphoinositide-dependent protein kinase-1, PDK1) activator (K\|d\|= 10.3 μM). Studies have indicated that this compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1). This is a distinct region separate from the ATP binding site.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Linear 1,3-diarylpropanoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Linear 1,3-diarylpropanoids
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Linear 1,3-diarylpropanoids
Alternative Parents	Cinnamic acids Styrenes Medium-chain fatty acids Halogenated fatty acids Chlorobenzenes Unsaturated fatty acids Aryl chlorides Monocarboxylic acids and derivatives Carboxylic acids Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Linear 1,3-diarylpropanoid - Cinnamic acid - Cinnamic acid or derivatives - Medium-chain fatty acid - Styrene - Chlorobenzene - Halobenzene - Halogenated fatty acid - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Fatty acyl - Fatty acid - Benzenoid - Unsaturated fatty acid - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organooxygen compound - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organochloride - Organohalogen compound - Organic oxide - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as linear 1,3-diarylpropanoids. These are organic compounds with a structure based on a C6-C3-C6 skeleton, where the two benzene rings are not linked together.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

pKa	pKₐ: 4.55 (Predicted)

Associated Targets(Human)

PRKCZ Tchem Protein kinase C zeta (2414 Activities)

Discover Target: PRKCZ

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 Activities)

Discover Target: PDPK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PKN2 Tchem Protein kinase N2 (1991 Activities)

Discover Target: PKN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)

Discover Target: AKT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDK1 Tchem Pyruvate dehydrogenase kinase isoform 1 (2021 Activities)

Discover Target: PDK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SGK1 Tchem Serine/threonine-protein kinase Sgk1 (2343 Activities)

Discover Target: SGK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KB1 Tchem Ribosomal protein S6 kinase 1 (4456 Activities)

Discover Target: RPS6KB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770282
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770282
IUPAC Name	(Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
INCHI	InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
InChIKey	LLJYFDRQFPQGNY-QINSGFPZSA-N
Smiles	C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl
Isomeric SMILES	C1=CC=C(C=C1)/C(=C\C(=O)O)/CCC2=CC=C(C=C2)Cl
WGK Germany	3
PubChem CID	44141940
Molecular Weight	286.76

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
C2505235	Certificate of Analysis	Aug 15, 2022	P343334
J2222427	Certificate of Analysis	Aug 15, 2022	P343334
J2222425	Certificate of Analysis	Aug 15, 2022	P343334
J2222426	Certificate of Analysis	Aug 15, 2022	P343334
J2222424	Certificate of Analysis	Aug 15, 2022	P343334

Chemical and Physical Properties

Solubility	Soluble in DMSO (>20 mg/ml), and ethanol (50 mM).
Sensitivity	Light sensitive
Refractive Index	n20D1.61 (Predicted)
Boil Point(°C)	~444.1° C at 760 mmHg (Predicted)
Molecular Weight	286.800 g/mol
XLogP3	5.000
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	286.076 Da
Monoisotopic Mass	286.076 Da
Topological Polar Surface Area	37.300 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	337.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xiao Wang, Zhen Li, Xiaojing Wu, Bingjie Liu, Tian Tian, Yi Ding, Haibo Zhang, Yuanli Li, Ye Liu, Chunai Dai. (2024) Self-Floating Polydopamine/Polystyrene Composite Porous Structure via a NaCl Template Method for Solar-Driven Interfacial Water Evaporation. Polymers, 16 (15): (2231).

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