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PROTAC CDK12/13 Degrader-1 TFA , CAS No.P658854

COA

Molecular Weight: 936.93

In stock

Item Number

P658854

Grouped product items
SKU	Size	Availability	Price
P658854-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
P658854-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
P658854-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,350.90

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Basic Description

Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PROTAC CDK12/13 Degrader-1 (7f) TFA is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC 50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 TFA has anti-proliferative activity and can be use Appearance:Solid IC50& Target:CDK12 2.2 nM (DC 50 ) CDK13 2.1 nM (DC 50 ) In Vitro:PROTAC CDK12/13 Degrader-1 (7f) TFA (0.02-10 μM, 150 h) significantly inhibits the proliferation of MFM223 and MDA-MB-231 cells in a dose-dependent manner. PROTAC CDK12/13 Degrader-1 (7f) TFA (500 nM, 4 h) can significantly degrade CDK12 and CDK13 of In Vivo:The pharmacokinetic parameters of PROTAC CDK12/13 Degrader-1 (7f) TFA in rats. Parameters oral (20mg/kg) iv (10mg/kg) ip (20mg/kg) iv (2.5mg/kg) t 1/2 (h) - 5.28 10.85 5.8 T max (h) 5.33 0.08 2.17 0.08 C max (ng/mL) 7.73 19892.4 24.79 1498.5 C ma Biological Activity:PROTAC CDK12/13 Degrader-1 (7f) TFA is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC 50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 TFA has anti-proliferative activity and can be use

Names and Identifiers

Smiles	O=C(NCC1=CC=CC=C1)N([C@H]2CC[C@H](NC3=NC=C(C#N)C=C3)CC2)C4=CC=C(N5CCN(C(CNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)CC5)C=C4.O=C(O)C(F)(F)F
Molecular Weight	936.93

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 25 mg/mL (26.68 mM; ultrasonic and warming and heat to 60°C)

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