Basic Description

Synonyms	Tetraoxahexadec-15-yn-1-oic acid \| MFCD22683284 \| AMY4485 \| Propargyl-PEG4-COOH \| Propyne-PEG3-CH2CH2COOH \| 4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid \| 3-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]propanoic acid \| 4,7,10,13-TETRAOXAHEXADEC-15-YNOIC ACID \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Propargyl-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with DC50 of 200 nM in THP-1 cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Product description Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Carboxylic acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Carboxylic acids
Intermediate Tree Nodes	Not available
Direct Parent	Carboxylic acids
Alternative Parents	Monocarboxylic acids and derivatives Dialkyl ethers Acetylides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic acyclic compounds
Substituents	Acetylide - Monocarboxylic acid or derivatives - Ether - Dialkyl ether - Carboxylic acid - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as carboxylic acids. These are compounds containing a carboxylic acid group with the formula -C(=O)OH.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	488202373
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202373
IUPAC Name	3-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]propanoic acid
INCHI	InChI=1S/C12H20O6/c1-2-4-15-6-8-17-10-11-18-9-7-16-5-3-12(13)14/h1H,3-11H2,(H,13,14)
InChIKey	WMBXAUWIPBFEOK-UHFFFAOYSA-N
Smiles	C#CCOCCOCCOCCOCCC(=O)O
Isomeric SMILES	C#CCOCCOCCOCCOCCC(=O)O
PubChem CID	77078488
Molecular Weight	260.279

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
G2307682	Certificate of Analysis	Jun 08, 2023	P412744
G2307689	Certificate of Analysis	Jun 08, 2023	P412744
G2307681	Certificate of Analysis	Jun 08, 2023	P412744
G2307729	Certificate of Analysis	Jun 08, 2023	P412744
G2307684	Certificate of Analysis	Jun 08, 2023	P412744
G2307688	Certificate of Analysis	Jun 08, 2023	P412744
G2307674	Certificate of Analysis	Jun 08, 2023	P412744
G2307686	Certificate of Analysis	Jun 08, 2023	P412744

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro
Refractive Index	1.460
Molecular Weight	260.279 g/mol
XLogP3	-0.800
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	13
Exact Mass	260.126 Da
Monoisotopic Mass	260.126 Da
Topological Polar Surface Area	74.200 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	244.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Documents & Articles

General Conjugation Protocols of PEG linkers——PEG Acid

Categories: Technical articles

Tags:

Buffer Polyglycolic acid Aqueous solution method organic solvent method

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Kun Chen, Guixin Wang, Xuedong Wang, Huili Wang. (2023) A smartphone-based ratiometric fluoroprobe based on blue-red dual-emission signals of thiochrome and copper nanoclusters for sensitive assay of metam-sodium in cucumbers. TALANTA, 261 (124673).

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SKU	Size	Availability	Price
P412744-100mg	100mg	3	$98.90
P412744-250mg	250mg	7	$177.90
P412744-1g	1g	4	$640.90
P412744-5g	5g	2	$2,883.90

Propargyl-PEG4-acid - 98%, high purity , CAS No.1415800-32-6