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Procarbazine HCl - ≥98%, high purity , DNA inhibitor, CAS No.366-70-1, DNA inhibitor

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
P129854
Grouped product items
SKU Size
Availability
 Price Qty
P129854-50mg
50mg
≥10
$25.90
P129854-250mg
250mg
7
$97.90
P129854-1g
1g
7
$299.90
P129854-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,346.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Clastogen and genotoxic carcinogen

View related series
Alkylating antitumor agents (6) Cell Cycle/DNA Damage (2602) DNA Alkylator/Crosslinker (72) DNA Damage (697) Pharmaceutical ingredients (367)

Basic Description

Synonyms Nathulane | DTXCID001190 | Ro 4-646711 | CCRIS 531 | Natulan hydrochloride | Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine [French] | FT-0603386 | Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine | Matulane | Natunalar
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Primaquine phosphate is an antineoplastic agent.Clastogen and genotoxic carcinogen. Induces chromosomal damage and mutations. Antineoplastic agent. Active in vivo and in vitro.
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type INHIBITOR
Mechanism of action DNA inhibitor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Procarbazine HCl is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.
An antineoplastic agent.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzoic acids and derivatives
Intermediate Tree Nodes Not available
Direct Parent Benzamides
Alternative Parents Benzoyl derivatives  Secondary carboxylic acid amides  Alkylhydrazines  Organopnictogen compounds  Organooxygen compounds  Organic oxides  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Benzamide - Benzoyl - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Alkylhydrazine - Hydrochloride - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrazine derivative - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as benzamides. These are organic compounds containing a carboxamido substituent attached to a benzene ring.
External Descriptors hydrochloride

Associated Targets(Human)

A498 (42825 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 Activities)
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CCRF-CEM (65223 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 205 (50209 Activities)
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DLD-1 (17511 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DMS-273 (14108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DU-145 (51482 Activities)
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HL-60 (67320 Activities)
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HT-29 (80576 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
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MOLT-4 (49676 Activities)
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OVCAR-3 (48710 Activities)
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OVCAR-4 (44535 Activities)
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OVCAR-5 (45555 Activities)
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OVCAR-8 (47708 Activities)
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PC-3 (62116 Activities)
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RPMI-8226 (44974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 393 (41971 Activities)
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RXF 631 (11415 Activities)
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SF-295 (48000 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 Activities)
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SK-MEL-28 (48833 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 Activities)
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SK-OV-3 (52876 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SN12C (47755 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-19 (46794 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-78 (14240 Activities)
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TK-10 (45540 Activities)
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U-251 (51189 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UACC-257 (46019 Activities)
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UACC-62 (47335 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UO-31 (46270 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
XF498 (12972 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
786-0 (47912 Activities)
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A549 (127892 Activities)
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NCI/ADR-RES (33767 Activities)
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T47D (39041 Activities)
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EKVX (44102 Activities)
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NCI-H322M (45589 Activities)
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HCC 2998 (41480 Activities)
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HCT-116 (91556 Activities)
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HOP-18 (11577 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HOP-92 (41141 Activities)
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Hs-578T (29457 Activities)
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NCI-H460 (60772 Activities)
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SF-268 (49410 Activities)
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Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
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Staphylococcus aureus (210822 Activities)
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Acinetobacter baumannii (41033 Activities)
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Escherichia coli (133304 Activities)
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Cryptococcus neoformans (21258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P388 (20296 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P388/ADR (1216 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
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Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488181015
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488181015
IUPAC Name 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride
INCHI InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
InChIKey DERJYEZSLHIUKF-UHFFFAOYSA-N
Smiles CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
Isomeric SMILES CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
WGK Germany 3
Molecular Weight 257.76
Reaxy-Rn 4024454
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4024454&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
D23211584 Certificate of Analysis Feb 07, 2025 P129854
D23211585 Certificate of Analysis Feb 07, 2025 P129854
D23211656 Certificate of Analysis Feb 07, 2025 P129854
D23211567 Certificate of Analysis Feb 07, 2025 P129854
F1509100 Certificate of Analysis Jan 25, 2023 P129854

Chemical and Physical Properties

Solubility Soluble in water (52 mg/ml at 25 °C), DMSO (≥18 mg/ml), methanol, and ethanol (52 mg/ml at 25 °C).
Melt Point(°C) 226 °C
Molecular Weight 257.760 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 5
Exact Mass 257.129 Da
Monoisotopic Mass 257.129 Da
Topological Polar Surface Area 53.200 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 210.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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