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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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P276607-1g
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1g |
2
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$64.90
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P276607-5g
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5g |
2
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$116.90
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P276607-25g
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25g |
2
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$526.90
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Glucocorticoid. Anti-inflammatory and potent immunosuppressive agent.
| Synonyms | Metacortandralone | Hydroretrocortine | 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione | 1-Dehydrocortisol, 1-Dehydrohydrocortisone | 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Glucocorticoid (K i = 4 nM). Anti-inflammatory and immunosuppressive agent. Recruits TIF-2 (EC 50 = 3 nM). Upregulates cdk inhibitors Plk3, Bcl-xl and p53. Shows antitumor effects in vivo. Orally active. |
| Storage Temp | Store at -20°C |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Action Type | AGONIST |
| Mechanism of action | Glucocorticoid receptor agonist |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description |
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Steroids and steroid derivatives |
| Subclass | Hydroxysteroids |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 21-hydroxysteroids |
| Alternative Parents | Gluco/mineralocorticoids, progestogins and derivatives 20-oxosteroids 3-oxo delta-1,4-steroids 17-hydroxysteroids 11-beta-hydroxysteroids Delta-1,4-steroids Tertiary alcohols Alpha-hydroxy ketones Secondary alcohols Cyclic ketones Cyclic alcohols and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic homopolycyclic compounds |
| Substituents | Progestogin-skeleton - 21-hydroxysteroid - 20-oxosteroid - Pregnane-skeleton - 3-oxo-delta-1,4-steroid - 3-oxosteroid - Oxosteroid - 11-beta-hydroxysteroid - 11-hydroxysteroid - 17-hydroxysteroid - Delta-1,4-steroid - Cyclic alcohol - Tertiary alcohol - Alpha-hydroxy ketone - Ketone - Secondary alcohol - Cyclic ketone - Primary alcohol - Alcohol - Hydrocarbon derivative - Organooxygen compound - Organic oxide - Organic oxygen compound - Carbonyl group - Aliphatic homopolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. |
| External Descriptors | C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives |
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| ALogP | 1.6 |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504750933 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750933 |
| IUPAC Name | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| INCHI | InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
| InChIKey | OIGNJSKKLXVSLS-VWUMJDOOSA-N |
| Smiles | CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O |
| Isomeric SMILES | C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O |
| Molecular Weight | 360.44 |
| Reaxy-Rn | 2339782 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2339782&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 04, 2025 | P276607 | |
| Certificate of Analysis | Mar 04, 2025 | P276607 | |
| Certificate of Analysis | Dec 18, 2024 | P276607 | |
| Certificate of Analysis | Dec 18, 2024 | P276607 | |
| Certificate of Analysis | Dec 18, 2024 | P276607 | |
| Certificate of Analysis | Oct 10, 2024 | P276607 | |
| Certificate of Analysis | May 25, 2024 | P276607 | |
| Certificate of Analysis | Sep 20, 2023 | P276607 | |
| Certificate of Analysis | Sep 20, 2023 | P276607 | |
| Certificate of Analysis | Sep 20, 2023 | P276607 | |
| Certificate of Analysis | Jan 17, 2023 | P276607 | |
| Certificate of Analysis | Sep 28, 2022 | P276607 | |
| Certificate of Analysis | Sep 28, 2022 | P276607 | |
| Certificate of Analysis | Dec 24, 2021 | P276607 | |
| Certificate of Analysis | Dec 24, 2021 | P276607 | |
| Certificate of Analysis | Dec 24, 2021 | P276607 |
| Solubility | Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone, slightly soluble in methylene chloride. It shows polymorphism |
|---|---|
| Flash Point(°C) | 2℃ |
| Boil Point(°C) | 412.46°C (rough estimate) |
| Melt Point(°C) | 240 °C (dec.)(lit.) |
| Molecular Weight | 360.400 g/mol |
| XLogP3 | 1.600 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 360.194 Da |
| Monoisotopic Mass | 360.194 Da |
| Topological Polar Surface Area | 94.800 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 724.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 7 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Starting at $158.90
| 1. Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li, Chengyu Lv. (2024) Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects. CHEMISTRY & BIODIVERSITY, (e202301525). |
| 2. Guozheng Zhao. (2023) Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. MOLECULES, 28 (18): (6619). |
| 3. Yunjia Wang, Zhongjing Jiang, Linhua Deng, Gengming Zhang, Xia Xu, Emmanuel Alonge, Hongqi Zhang, Chaofeng Guo. (2023) Dendrobium offificinale polysaccharides prevents glucocorticoids-induced osteoporosis by destabilizing KEAP1-NRF2 interaction. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (126600). |
| 4. Haoyu Long, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. (2023) Chromatographic separation performance of silica microspheres surface-modified with triazine-containing imine-linked covalent organic frameworks. TALANTA, 260 (124589). |
| 5. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen. (2023) Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application. FOOD CHEMISTRY, 421 (136196). |
| 6. Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li. (2023) Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways. INTERNATIONAL IMMUNOPHARMACOLOGY, 118 (110079). |
| 7. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PHARMSCITECH, 23 (7): (1-13). |
| 8. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li. (2020) Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease. JOURNAL OF ETHNOPHARMACOLOGY, 254 (112764). |
| 9. Shoubao Wang, Yao Xiong, Yinmin Wang, Jingting Chen, Jun Yang, Binbin Sun. (2020) Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft – an experimental study. TRANSPLANT INTERNATIONAL, 33 (4): (450-461). |
| 10. Jia-Bi Lin, Hao Wu, Yu-Ling Liu, Pang-Chui Shaw, Pei-Bo Li. (2019) Transcriptome analysis reveals functional roles of nacreous protein N16 in prednisolone-induced osteoporotic zebrafish. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 122 (1071). |
| 11. Guozheng Zhao. (2024) Detection of six glucocorticoids using a nanogold-glucocorticoid receptor-based biosensor. CHEMICAL PHYSICS LETTERS, 856 (141611). |
| 12. Guowen Li, Mengjia Chao, Chun Zhang, Hang Gao, Xiuping Li, Hongxin Ren, Xinlin Wei, Chifang Peng, Wei Ma, Zhouping Wang. (2025) Supraparticle Nanoarchitectonics with Bright Gold Nanoclusters Induced by Host–Guest Recognition for Volatile Amine and Meat Freshness Detection. ACS Applied Nano Materials, |