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PQ 401 - 10mM in DMSO, high purity , CAS No.196868-63-0(DMSO), Inhibitor of Insulin-like growth factor I receptor

COA

Grade & Purity:

Moligand™

10mM in DMSO

Cas Number: 196868-63-0(DMSO)
Molecular Weight: 341.79

In stock

Item Number

P408859

Grouped product items
SKU	Size	Availability	Price	Qty
P408859-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$232.90

IGF-1R Inhibitors

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Compound libraries (12325)

Basic Description

Synonyms	N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Insulin-like growth factor I receptor
Product Description	Information PQ 401 PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM. In vitro PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells. In vivo PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner. Cell Data cell lines： Concentrations：~50 μM Incubation Time：3 days Powder Purity:≥99%

Associated Targets(Human)

IGF1R Tclin Insulin-like growth factor 1 receptor (1 Activities)

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(=C2)C)C=C(Cl)C=C1
Molecular Weight	341.79

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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