Basic Description

Synonyms	SCHEMBL16132816 \| BP-23701 \| CS-0197881 \| MS-23445 \| 4-(2-Pyridinyldithio)pentanoic acid \| (S)-4-(pyridin-2-yldisulfaneyl)pentanoic acid \| 4-(pyridin-2-yldisulfanyl)pentanoic acid \| SCHEMBL1395632 \| AKOS040758140 \| HY-141664
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	PPA is an ADC linker (US20060073528A1). PPA can be used for making antibody-drug conjugate.
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PPA is an ADC linker (US20060073528A1). PPA can be used for making antibody-drug conjugate Form:Solid IC50& Target:Disulfide Cleavable

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Fatty Acyls
    - Subclass Fatty acids and conjugates

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Fatty Acyls
Subclass	Fatty acids and conjugates
Intermediate Tree Nodes	Not available
Direct Parent	Thia fatty acids
Alternative Parents	Pyridines and derivatives Heteroaromatic compounds Organic disulfides Sulfenyl compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Thia fatty acid - Pyridine - Heteroaromatic compound - Organic disulfide - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Sulfenyl compound - Organoheterocyclic compound - Azacycle - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic oxide - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as thia fatty acids. These are fatty acid derivatives obtained by insertion of a sulfur atom at specific positions in the chain.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	4-(pyridin-2-yldisulfanyl)pentanoic acid
INCHI	InChI=1S/C10H13NO2S2/c1-8(5-6-10(12)13)14-15-9-4-2-3-7-11-9/h2-4,7-8H,5-6H2,1H3,(H,12,13)
InChIKey	OOUPHXWHXYLQBK-UHFFFAOYSA-N
Smiles	CC(CCC(=O)O)SSC1=CC=CC=N1
Isomeric SMILES	CC(CCC(=O)O)SSC1=CC=CC=N1
Alternate CAS	452072-22-9
PubChem CID	11536061
Molecular Weight	243.35

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (410.93 mM; Need ultrasonic)
Molecular Weight	243.400 g/mol
XLogP3	2.000
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	243.039 Da
Monoisotopic Mass	243.039 Da
Topological Polar Surface Area	101.000 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	202.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ying Li, Liya Niu, Chao Sun, Dongming Li, Zicong Zeng, Jianhui Xiao. (2023) Effect of Medium Chain Triglycerides on the Digestion and Quality Characteristics of Tea Polyphenols-Fortified Cooked Rice. Foods, 12 (23): (4366).
2. Yurong Bai, Mei Xiang, Zhenhua Zhou, Zhiqiang Mao, Fan Zhang. (2024) Engineering ATP activated reversible nanochannel for gating of ion transport. SENSORS AND ACTUATORS B-CHEMICAL, 402 (135100).
3. Yun Li, Liya Niu, Leiyan Wu, Dongming Li, Chao Sun, Jianhui Xiao. (2023) Polyphenol-fortified extruded sweet potato starch vermicelli: Slow-releasing polyphenols is the main factor that reduces the starch digestibility. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (127584).
4. Shiqin Sun, Yanshun Li, Ruixiang Sun, Luzhen Jiao, Shiwei Liu, Shitao Yu. (2024) Tailoring Zn-based diacidic functionalization of Deep eutectic solvent Catalyst: Green and efficient synthesis of ε-Caprolactam under mild conditions. FUEL, 357 (129777).
5. Yun Li, Liya Niu, Chao Sun, Jin Tu, Jianhui Xiao. (2023) Comparison of in vitro starch digestibility and structure of matcha-fortified starch vermicelli from different botanical sources. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,
6. Shuming Wu, Yanwei Li, Tinghong Wang, Hao Li, Xinna Wang, Lijuan Ma, Nazhen Zhang, Penghan Yue, Yanhui Li. (2023) Design and synthesis of dual functional porphyrin-based COFs as highly selective adsorbent and photocatalyst. CHEMICAL ENGINEERING JOURNAL, 470 (144135).
7. Songtao Liu, Rui Yan, Muhammad Humayun, Huanli Zhang, Yang Qu, Yingxue Jin. (2022) Pyropheophorbide-a/(001) TiO2 Nanocomposites with Enhanced Charge Separation and O2 Adsorption for High-Efficiency Visible-Light Degradation of Ametryn. MOLECULES, 27 (17): (5576).
8. Wenjuan Li, Xingjiang Liu, Ailing Sun, Liuhe Wei, Rui Li, Hangyu He, Shaoli Yang, Shizhuo Wang, Yanfen Niu, Yuhan Li. (2021) Exploring piperazine for intrinsic weather-proof, robust and self-healable poly(urethane urea) toward surface and tire protection. POLYMER, 227 (123829).
9. Xiaoguang Pei, Weiyu Fan. (2021) Influence of Compound Modification of Oil Sands De-Oiled Asphalt and Polyphosphoric Acid on High- and Low-Temperature Performance of Styrene-Butadiene-Styrene-Modified Asphalt. Materials, 14 (4): (797).
10. Guoxing Yu, Chao Ma, Juan Li. (2020) Flame retardant effect of cytosine pyrophosphate and pentaerythritol on polypropylene. COMPOSITES PART B-ENGINEERING, 180 (107520).
11. Wen Zhang, An Bu, Qingyuan Ji, Luofu Min, Song Zhao, Yuxin Wang, Jing Chen. (2019) pKa-Directed Incorporation of Phosphonates into MOF-808 via Ligand Exchange: Stability and Adsorption Properties for Uranium. ACS Applied Materials & Interfaces, 11 (37): (33931–33940).
12. Qiuxia Fu, Yang Si, Cheng Duan, Zishuo Yan, Lifang Liu, Jianyong Yu, Bin Ding. (2019) Highly Carboxylated, Cellular Structured, and Underwater Superelastic Nanofibrous Aerogels for Efficient Protein Separation. ADVANCED FUNCTIONAL MATERIALS, 29 (13): (1808234).
13. Jinbin Liu, Jing Jiang, Yajun Bai, Tai-ping Fan, Ye Zhao, Xiaohui Zheng, Yujie Cai. (2018) Mimicking a New 2-Phenylethanol Production Pathway from Proteus mirabilis JN458 in Escherichia coli. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (13): (3498–3504).
14. Zhen Hu, Qing Shao, Mark G. Moloney, Xirong Xu, Dayu Zhang, Jun Li, Chunhua Zhang, Yudong Huang. (2017) Nondestructive Functionalization of Graphene by Surface-Initiated Atom Transfer Radical Polymerization: An Ideal Nanofiller for Poly(p-phenylene benzobisoxazole) Fibers. MACROMOLECULES, 50 (4): (1422–1429).
15. Miaomiao Han, Xiao Liu, Guangcheng Huang, Yadong Liu, Shengxiang Ji. (2016) Phosphoric acid doped polybenzimidazole as an heterogeneous catalyst for selective and efficient dehydration of saccharides to 5-hydroxymethylfurfural. RSC Advances, 6 (53): (47890-47896).
16. Zhidong Zhang, Yingxin Liu, Xin Chen, Zhengzhong Shao. (2016) Multi-responsive polyethylene-polyamine/gelatin hydrogel induced by non-covalent interactions. RSC Advances, 6 (54): (48661-48665).
17. Zhihu Yan, Caili Dai, Mingwei Zhao, Guang Zhao, Yuyang Li, Xuepeng Wu, Yifei Liu, Mingyong Du. (2015) Multi-Responsive Wormlike Micelles Based on N-alkyl-N-Methylpiperidinium Bromide Cationic Surfactant. JOURNAL OF SURFACTANTS AND DETERGENTS, 18 (5): (739-746).
18. Yan Zhihu, Dai Caili, Zhao Mingwei, Li Yuyang, Du Mingyong, Peng Dongxu. (2015) Study of pH-responsive surface active ionic liquids: the formation of spherical and wormlike micelles. COLLOID AND POLYMER SCIENCE, 293 (6): (1759-1766).
19. Lubiao Liu, Chuangmin Li, Qinhao Deng, Youwei Gan, Wei Liao. (2024) Study on the high-temperature performance and self-healing capability of asphalt modified with pyrolysis oil from waste tires and polyphosphoric acid. Case Studies in Construction Materials, 20 (e03291).

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SKU	Size	Availability	Price
P650899-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$125.90
P650899-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$200.90
P650899-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$320.90

PPA - 99%, high purity , CAS No.452072-22-9