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PNU 74654 - ≥98%, high purity , CAS No.113906-27-7

1 Citations

COA

Grade & Purity:

≥98%

Cas Number: 113906-27-7
Molecular Weight: 320.34
PubChem CID: 9836739
PubChem SID: 504764940

In stock

Item Number

P276267

Grouped product items
SKU	Size	Availability	Price
P276267-5mg	5mg	3	$64.90
P276267-10mg	10mg	3	$97.90
P276267-25mg	25mg	3	$195.90
P276267-50mg	50mg	3	$347.90
P276267-100mg	100mg	2	$619.90
P276267-250mg	250mg	2	$1,395.90

Wnt signaling pathway blocker

View related series

Apoptosis (4276) Stem Cell/Wnt (1019) Wnt (104) β-catenin (56)

Basic Description

Synonyms	HMS3413P04 \| HY-101130 \| PNU74654 \| PNU-74654 \| J-003040 \| NSC755984 \| NSC-755984 \| CCG-208115 \| N-[(E)-(5-Methylfuran-2-yl)methylideneamino]-2-phenoxybenzamide \| SCHEMBL3514174 \| BDBM50436058 \| CS-6211 \| AC-33054 \| PNU 74654 \| 2-Phenoxybenzoic acid-[(5-m
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Wnt signaling pathway blocker. Inhibits Wnt/β-catenin pathway. Blocks the protein-protein interaction between β-catenin and TCF. Antitumor effects.PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell f
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. application： PNU-74654 has been used: as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Diphenylethers

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Diphenylethers
Intermediate Tree Nodes	Not available
Direct Parent	Diphenylethers
Alternative Parents	Diarylethers Benzoic acids and derivatives Phenoxy compounds Phenol ethers Benzoyl derivatives Heteroaromatic compounds Furans Oxacyclic compounds Carboxylic acids and derivatives Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Diphenylether - Diaryl ether - Benzoic acid or derivatives - Benzoyl - Phenoxy compound - Phenol ether - Heteroaromatic compound - Furan - Oxacycle - Organoheterocyclic compound - Ether - Carboxylic acid derivative - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Organic oxide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CTNNB1 Tchem Catenin beta-1 (1 Activities)

Discover Target: CTNNB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CTNNB1 Tchem Catenin beta-1 (517 Activities)

Discover Target: CTNNB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTNNB1 Tchem TCF4/beta-catenin (616 Activities)

Discover Target: CTNNB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTNNB1 Tchem TCF4-CTNNB1 complex (25 Activities)

Discover Target: CTNNB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504764940
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504764940
IUPAC Name	N-[(E)-(5-methylfuran-2-yl)methylideneamino]-2-phenoxybenzamide
INCHI	InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
InChIKey	JJEDWBQZCRESJL-DEDYPNTBSA-N
Smiles	CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
Isomeric SMILES	CC1=CC=C(O1)/C=N/NC(=O)C2=CC=CC=C2OC3=CC=CC=C3
PubChem CID	9836739
Molecular Weight	320.34

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
L2416335	Certificate of Analysis	Dec 25, 2024	P276267
C2215570	Certificate of Analysis	Sep 20, 2023	P276267
C2215600	Certificate of Analysis	Sep 20, 2023	P276267
C2215612	Certificate of Analysis	Sep 20, 2023	P276267
C2215598	Certificate of Analysis	Sep 20, 2023	P276267
C2215599	Certificate of Analysis	Sep 20, 2023	P276267
C2215601	Certificate of Analysis	Sep 20, 2023	P276267

Chemical and Physical Properties

Solubility	Soluble in DMSO to 75 mM
Molecular Weight	320.300 g/mol
XLogP3	4.200
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	320.116 Da
Monoisotopic Mass	320.116 Da
Topological Polar Surface Area	63.800 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	434.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Fang Lini, Tao Yang, Che Guoying, Yun Yongzi, Ren Min, Liu Yujie. (2024) WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination. MOLECULAR MEDICINE, 30 (1): (1-16).

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PNU 74654 - ≥98%, high purity , CAS No.113906-27-7

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Citations of This Product

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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