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PNU 282987 - ≥98%(HPLC), high purity , CAS No.711085-63-1, Agonist of nicotinic acetylcholine receptor α7 subunit

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 711085-63-1
Molecular Weight: 264.75
MDL number: MFCD08703110
PubChem CID: 9795278
PubChem SID: 504764857

In stock

Item Number

P288832

Grouped product items
SKU	Size	Availability	Price
P288832-5mg	5mg	3	$59.90
P288832-25mg	25mg	7	$227.90
P288832-50mg	50mg	5	$350.90
P288832-100mg	100mg	5	$630.90

Selective α7 nAChR agonist

View related series

Class A GPCR (4138) Ion channel (2197) Membrane Transporter/Ion Channel (1822) nAChR (140) Neuronal Signaling (3320) nicotinic acetylcholine receptor α7 subunit Agonist (13)

Basic Description

Synonyms	AKOS016339643 \| PNU-282987 (free base) \| PNU282987.HCl \| EX-A3238 \| PNU282987 \| PNU-282987 \| HMS3677E04 \| MFCD08703110 \| P2774 \| AC-35375 \| BDBM50161764 \| HY-12560 \| BCP0726000208 \| BDBM50161753 \| BRD-K28863208-001-01-2 \| J-004946 \| (R)-4-Chloro-N-(quinuc
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Highly selectiveα7 nAChR agonist (Ki= 26 nM) displaying negligible blockade ofα1β1γδandα3β4nAChRs (IC50≥ 60μM). Found to be inactive against a panel of 32 receptors at 1μM, except 5-HT3receptors (Ki= 930 nM).
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of nicotinic acetylcholine receptor α7 subunit
Product Description	Product description： PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives
      - Level5 Halobenzoic acids and derivatives
        Level6 4-halobenzoic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Halobenzoic acids and derivatives
Direct Parent	4-halobenzoic acids and derivatives
Alternative Parents	Benzamides Quinuclidines Benzoyl derivatives Chlorobenzenes Piperidines Aryl chlorides Trialkylamines Secondary carboxylic acid amides Amino acids and derivatives Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	4-halobenzoic acid or derivatives - Benzamide - Benzoyl - Quinuclidine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Piperidine - Amino acid or derivatives - Carboxamide group - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organooxygen compound - Organic nitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 4-halobenzoic acids and derivatives. These are benzoic acids or derivatives carrying a halogen atom at the 4-position of the benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 (3 Activities)

Discover Target: CHRNA7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A (1 Activities)

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504764857
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504764857
IUPAC Name	N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide
INCHI	InChI=1S/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/m0/s1
InChIKey	WECKJONDRAUFDD-ZDUSSCGKSA-N
Smiles	C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl
Isomeric SMILES	C1CN2CCC1[C@H](C2)NC(=O)C3=CC=C(C=C3)Cl
PubChem CID	9795278
Molecular Weight	264.75

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
F2306095	Certificate of Analysis	Apr 28, 2023	P288832
F2306092	Certificate of Analysis	Apr 28, 2023	P288832
F2306096	Certificate of Analysis	Apr 28, 2023	P288832
F2306099	Certificate of Analysis	Apr 28, 2023	P288832
F2306094	Certificate of Analysis	Apr 28, 2023	P288832
F2306093	Certificate of Analysis	Apr 28, 2023	P288832
F2306097	Certificate of Analysis	Apr 28, 2023	P288832
F2306098	Certificate of Analysis	Apr 28, 2023	P288832

Chemical and Physical Properties

Solubility	Solvent:1eq. HCl, Max Conc. mg/mL: 26.48, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 26.48, Max Conc. mM: 100
Sensitivity	Air Sensitive
Melt Point(°C)	168 °C
Molecular Weight	264.750 g/mol
XLogP3	2.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	264.103 Da
Monoisotopic Mass	264.103 Da
Topological Polar Surface Area	32.299 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	307.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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