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PMX205, Antagonist of C5a 1 receptor, CAS No.514814-49-4, Antagonist of C5a 1 receptor

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rp174792
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rp174792-500μg
500μg
Available within 8-12 weeks(?)
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$1,334.90
rp174792-1mg
1mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$2,334.90
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C5a1 receptor Antagonist (17)

Basic Description

Product Name PMX205, Antagonist of C5a 1 receptor, CAS No.514814-49-4
Synonyms Cyclic hexapeptide complement C5a antagonist | Hydrocinnamate-(orn-Pro-dcha-Trp-Arg) | SCHEMBL12971708 | EX-A5705 | HC-[OP(D-Cha)WR] | PMX 205 | CHEBI:144869 | LP-16 | A16946 | HY-110136 | N-((3R,6S,9S,15S,20AS)-6-((1H-indol-3-yl)methyl)-3-(cyclohexylmeth
Grade Moligand™
Specifications & Purity Moligand™
Action Type ANTAGONIST
Mechanism of action Antagonist of C5a 1 receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct Parent Oligopeptides
Alternative Parents Cyclic peptides  N-acyl-alpha amino acids and derivatives  Macrolactams  3-alkylindoles  Substituted pyrroles  Fatty amides  Benzene and substituted derivatives  Tertiary carboxylic acid amides  Pyrrolidines  Heteroaromatic compounds  Secondary carboxylic acid amides  Lactams  Guanidines  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Carboximidamides  Carbonyl compounds  Hydrocarbon derivatives  Organic oxides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Alpha-oligopeptide - Cyclic alpha peptide - N-acyl-alpha amino acid or derivatives - Macrolactam - Alpha-amino acid or derivatives - 3-alkylindole - Indole or derivatives - Indole - Fatty amide - Benzenoid - Monocyclic benzene moiety - Fatty acyl - Substituted pyrrole - Pyrrolidine - Heteroaromatic compound - Pyrrole - Tertiary carboxylic acid amide - Carboxamide group - Guanidine - Lactam - Secondary carboxylic acid amide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Azacycle - Carboximidamide - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors Not available

Associated Targets(Human)

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

CAS 514814-49-4

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names Cyclic hexapeptide complement C5a antagonist | Hydrocinnamate-(orn-Pro-dcha-Trp-Arg) | SCHEMBL12971708 | EX-A5705 | HC-[OP(D-Cha)WR] | PMX 205 | CHEBI:144869 | LP-16 | A16946 | HY-110136 | N-((3R,6S,9S,15S,20AS)-6-((1H-indol-3-yl)methyl)-3-(cyclohexylmeth
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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