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Pleuromutilin - 95%, high purity , CAS No.125-65-5

COA

Grade & Purity:

≥95%

Cas Number: 125-65-5
Molecular Weight: 378.51
PubChem CID: 46782767
PubChem SID: 488201358

In stock

Item Number

P329427

Grouped product items
SKU	Size	Availability	Price
P329427-5g	5g	6	$9.90
P329427-25g	25g	4	$19.90
P329427-100g	100g	2	$49.90

a potent diterpene antibiotic with activity against Gram positive bacteria

View related series

Antibiotic (1629) Bacterial (3013)

Basic Description

Synonyms	PLEUROMULIN \| (3aS,4R,5S,6S,8R,9R,9aR,12R)-5-Hydroxy-4,6,9,12-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl 2-hydroxyacetate \| HY-N2301 \| [(2R,3S,4S,6R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8
Specifications & Purity	≥95%
Source	Pleurotus
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Pleuromutilin is a potent diterpene antibiotic with activity against gram-positive bacteria. The antibiotic was isolated in 1951 from the genus\|Pleurotus.\|It has been demonstrated through crystallization and biochemical research that Pleuromutilins acts by blocking substrate binding to the donor site and acceptor site of the ribosome's peptidyl-transferase center, which results in inhibition of the peptide bond formation. The compound encounters minimum cross-resistance with other compounds, which is attributed to its mode of action. Pleuromutilins targets a wide spectrum of pathogens and has been used in skin and respiratory tract infection studies.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Prenol lipids
    - Subclass Diterpenoids
      - Level5 Mutilane diterpenoids
        Level6 Mutilin derivatives
        Level7 Pleuromutilin and derivatives

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Prenol lipids
Subclass	Diterpenoids
Intermediate Tree Nodes	Mutilane diterpenoids - Mutilin derivatives
Direct Parent	Pleuromutilin and derivatives
Alternative Parents	Secondary alcohols Ketones Carboxylic acid esters Monocarboxylic acids and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives
Molecular Framework	Aliphatic homopolycyclic compounds
Substituents	Pleuromutilin - Secondary alcohol - Ketone - Carboxylic acid ester - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as pleuromutilin and derivatives. These are mutilins with a hydroxyacetate derivative attached to the C8 carbon atom of the cyclopenta[8]annulene moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	488201358
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201358
IUPAC Name	[(2R,3S,4S,6R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-hydroxyacetate
INCHI	InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21?,22?/m1/s1
InChIKey	ZRZNJUXESFHSIO-JKZASVEESA-N
Smiles	CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CO)C
Isomeric SMILES	C[C@@H]1CCC23CCC(=O)[C@H]2C1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CO)C
PubChem CID	46782767
Molecular Weight	378.51

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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9 results found

Lot Number	Certificate Type	Date	Item
C2426330	Certificate of Analysis	Mar 08, 2024	P329427
C2426332	Certificate of Analysis	Mar 08, 2024	P329427
C2426334	Certificate of Analysis	Mar 08, 2024	P329427
F2308217	Certificate of Analysis	May 08, 2023	P329427
F2308214	Certificate of Analysis	May 08, 2023	P329427
F2308337	Certificate of Analysis	May 08, 2023	P329427
F2308335	Certificate of Analysis	May 08, 2023	P329427
F2308165	Certificate of Analysis	May 08, 2023	P329427
F2308628	Certificate of Analysis	May 08, 2023	P329427

Chemical and Physical Properties

Solubility	Soluble in ethanol, methanol, DMF and DMSO. Limited water solubility.
Molecular Weight	378.500 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	378.241 Da
Monoisotopic Mass	378.241 Da
Topological Polar Surface Area	83.800 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	645.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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