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PKM2 activator 2 - 10mM in DMSO, high purity , CAS No.1186660-06-9(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1186660-06-9(DMSO)
Molecular Weight: 452.49

In stock

Item Number

P655024

Grouped product items
SKU	Size	Availability	Price	Qty
P655024-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$165.90

View related series

Compound libraries (12325) Metabolic Enzyme/Protease (4860) Pyruvate Kinase (17)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	PKM2 activator 2 is a pyruvate kinase M2 ( PKM2 ) activitor with an AC 50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PKM2 activator 2 is a pyruvate kinase M2 ( PKM2 ) activitor with an AC 50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells In Vitro PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines. PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC 50 value of 66 nM in the luciferase-coupled assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:PKM2 66 nM (EC 50 )

Names and Identifiers

Smiles	FC1=C(S(=O)(N2CCN(S(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)=O)C(F)=CC=C1
Molecular Weight	452.49

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