Skip to the beginning of the images gallery

PKI 166 hydrochloride - ≥98%(HPLC), high purity , CAS No.2230253-82-2

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 2230253-82-2
Molecular Weight: 366.84
PubChem CID: 91691117

In stock

Item Number

P287660

Grouped product items
SKU	Size	Availability	Price
P287660-1mg	1mg	3	$39.90
P287660-5mg	5mg	3	$149.90
P287660-10mg	10mg	3	$175.90
P287660-25mg	25mg	3	$479.90
P287660-50mg	50mg	2	$759.90

Potent EGFR-kinase inhibitor

View related series

EGFR (254) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	4-[4-[[(1R)-1-Phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol hydrochloride
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	PKI 166 hydrochloride is a potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bi
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

IUPAC Name	4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol;hydrochloride
INCHI	InChI=1S/C20H18N4O.ClH/c1-13(14-5-3-2-4-6-14)23-19-17-11-18(24-20(17)22-12-21-19)15-7-9-16(25)10-8-15;/h2-13,25H,1H3,(H2,21,22,23,24);1H/t13-;/m1./s1
InChIKey	ZPTWAAIZEGWMGX-BTQNPOSSSA-N
Smiles	CC(C1=CC=CC=C1)NC2=NC=NC3=C2C=C(N3)C4=CC=C(C=C4)O.Cl
Isomeric SMILES	C[C@H](C1=CC=CC=C1)NC2=NC=NC3=C2C=C(N3)C4=CC=C(C=C4)O.Cl
PubChem CID	91691117
Molecular Weight	366.84

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
G2422186	Certificate of Analysis	Apr 09, 2024	P287660
G2422187	Certificate of Analysis	Apr 09, 2024	P287660
G2422188	Certificate of Analysis	Apr 09, 2024	P287660
G2422189	Certificate of Analysis	Apr 09, 2024	P287660
G2422191	Certificate of Analysis	Apr 09, 2024	P287660
G2422192	Certificate of Analysis	Apr 09, 2024	P287660
G2422193	Certificate of Analysis	Apr 09, 2024	P287660
G2422194	Certificate of Analysis	Apr 09, 2024	P287660
G2422185	Certificate of Analysis	Apr 09, 2024	P287660
G2422190	Certificate of Analysis	Apr 09, 2024	P287660

Chemical and Physical Properties

Solubility	DMSO(Maximum concentration 100 mM); Ethanol(Maximum concentration 50 mM)

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration