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PIKfyve-IN-1 - 95%, high purity , CAS No.2857982-26-2

COA

Grade & Purity:

≥95%

Cas Number: 2857982-26-2
Molecular Weight: 331.41

In stock

Item Number

P650468

Grouped product items
SKU	Size	Availability	Price	Qty
P650468-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
P650468-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$910.90

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PI3K/Akt/mTOR (765) PIKfyve (9)

Basic Description

Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology In Vitro PIKfyve-IN-1 inhibits PIKfyve in PIKfyve enzymatic assay and PIKfyve NanoBRET assay with IC 50 values of 6.9 nM and 4.01 nM, respectively. PIKfyve-IN-1 (0-10 μM) disrupts multiple phases of the lifecycle of coronaviruses: viral replication and viral entry. PIKfyve-IN-1 inhibits MHV replication and SARS-CoV-2 replication with IC 50 values of 23.5 nM and 19.5 nM, respectively. PIKfyve-IN-1 (5 μM) impacts lysosomal homeostasis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: Calu-3 cells Concentration: 1 μM Incubation Time: 1 h Result: Inhibited the uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein. Form:Solid IC50& Target:IC50: 6.9 nM (PIKfyve)

Names and Identifiers

Smiles	NC1=NC=C(CCC2)C(C3=C2NC4=C3C=C(C#CCN(C)C)C=C4)=N1
Molecular Weight	331.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

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