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PIK-93 - ≥96%, high purity , CAS No.593960-11-3, Inhibitor of phosphatidylinositol 4-kinase beta

COA COA
In stock
Item Number
P126888
Grouped product items
SKU Size
Availability
 Price Qty
P126888-1mg
1mg
3
$46.90
P126888-5mg
5mg
7
$99.90
P126888-25mg
25mg
7
$450.90
P126888-100mg
100mg
5
$1,620.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor

View related series
Anti-infection (2803) phosphatidylinositol 4-kinase beta Inhibitor (4) PI3K (243) PI3K/Akt/mTOR (765) PI4K (21) Virus (1811) Virus Protease (105)

Basic Description

Synonyms DTXSID30425868 | N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide | NCGC00346536-01 | MLS006010977 | Q27088391 | Chloroform, deutero- | N-[(2Z)-5-{4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2(3H)
Specifications & Purity Moligand™, ≥96%
Biochemical and Physiological Mechanisms PIK93 is also known as N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide. It inhibits poliovirus (PV) and coxsackievirus B3 (CVB3) viral RNA production and virus replication. PIK93 also prevents translation mediated
Storage Temp Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of phosphatidylinositol 4-kinase beta
Product Description

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively.


Product Application：

PIK93 has been used to examine if the accumulation of SNX27–retromer cargoes in FAM21 (family with sequence similarity 21) depleted cells is caused by an elevation of phosphatidylinositol 4-phosphate [PI(4)P] levels at the Golgi.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzenesulfonamides
Intermediate Tree Nodes Not available
Direct Parent Benzenesulfonamides
Alternative Parents Benzenesulfonyl compounds  N-acetylarylamines  2,4,5-trisubstituted thiazoles  Chlorobenzenes  Aryl chlorides  Organosulfonamides  Acetamides  Aminosulfonyl compounds  Heteroaromatic compounds  Secondary carboxylic acid amides  Azacyclic compounds  Alkanolamines  Organochlorides  Carbonyl compounds  Organopnictogen compounds  Primary alcohols  Hydrocarbon derivatives  Organic oxides  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Benzenesulfonamide - N-acetylarylamine - Benzenesulfonyl group - 2,4,5-trisubstituted 1,3-thiazole - N-arylamide - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Organosulfonic acid amide - Acetamide - Heteroaromatic compound - Aminosulfonyl compound - Thiazole - Sulfonyl - Azole - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Alkanolamine - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Alcohol - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organosulfur compound - Primary alcohol - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors sulfonamide - 1,3-thiazole - monochlorobenzenes

Associated Targets(Human)

PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (5 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PI4KB Tchem Phosphatidylinositol 4-kinase beta (3 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PRKDC Tchem DNA-dependent protein kinase (1929 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3CD Tclin PI3-kinase p110-delta subunit (6699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3CG Tclin PI3-kinase p110-gamma subunit (5411 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PI4KA Tchem PI4-kinase alpha subunit (184 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PI4KB Tchem PI4-kinase beta subunit (1593 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3CB Tchem PI3-kinase p110-beta subunit (4044 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Huh-7 (12904 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3C2B Tchem Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (438 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3C3 Tchem Phosphatidylinositol 3-kinase catalytic subunit type 3 (535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3C2A Tchem Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (139 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3C2G Tchem Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma (327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

PIK3CA PI3-kinase p110-alpha subunit (51 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
C2C12 (756 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764314
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764314
IUPAC Name N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide
INCHI InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
InChIKey JFVNFXCESCXMBC-UHFFFAOYSA-N
Smiles CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO
Isomeric SMILES CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO
WGK Germany 3
Molecular Weight 389.88
Reaxy-Rn 12231903
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12231903&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
F2316376 Certificate of Analysis Mar 04, 2025 P126888
F2316375 Certificate of Analysis Mar 04, 2025 P126888
F2316377 Certificate of Analysis Mar 04, 2025 P126888
F2316686 Certificate of Analysis Mar 04, 2025 P126888
F2316690 Certificate of Analysis Mar 04, 2025 P126888
F2316387 Certificate of Analysis Mar 04, 2025 P126888
F2316381 Certificate of Analysis Mar 04, 2025 P126888
F2316372 Certificate of Analysis Mar 04, 2025 P126888

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 38.99, Max Conc. mM: 100
Sensitivity light sensitive
Molecular Weight 389.900 g/mol
XLogP3 1.400
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 6
Exact Mass 389.027 Da
Monoisotopic Mass 389.027 Da
Topological Polar Surface Area 145.000 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 543.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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