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Phloridzin - ≥98%, high purity , CAS No.60-81-1, Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of SGLT6;Inhibitor of SMIT

15 Citations COA COA
In stock
Item Number
P139206
Grouped product items
SKU Size
Availability
 Price Qty
P139206-250mg
250mg
5
$19.90
P139206-1g
1g
5
$64.90
P139206-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$247.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Potent, competitive SGLT inhibitor

View related series
major facilitator superfamily domain containing 4B Inhibitor (2) Membrane Transporter (607) Membrane Transporter/Ion Channel (1822) Na+/K+ ATPase (41) SGLT (27) SGLT6 Inhibitor (1) SMIT Inhibitor (1)

Basic Description

Synonyms BRD-K73756878-001-02-9 | BSPBio_002674 | Phlorrhizin | CCG-38341 | DivK1c_006421 | SCHEMBL17290 | SDCCGMLS-0066626.P001 | Phlorizoside | s2343 | 1-Propanone, 1-[2-(beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)- | O-glucoside, 1 | Phlo
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Potent, competitive SGLT inhibitor (IC 50 values are 400 and 65 nM for SGLT1 and SLGT2 respectively). Induces renal glycosuria and blocks intestinal glucose absorption in vivo. Orally active.
Shipped In Normal
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of SGLT6;Inhibitor of SMIT
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Phloridzin is a dihydrochalcone found in all parts of the apple tree, except the mature fruit, and acts as an inhibitor of SGLT-1 and SGLT-2.
An SGLT-1 and SGLT-2 inhibitor found in apple trees

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Flavonoids
Subclass Flavonoid glycosides
Intermediate Tree Nodes Not available
Direct Parent Flavonoid O-glycosides
Alternative Parents 2'-Hydroxy-dihydrochalcones  Cinnamylphenols  Phenolic glycosides  Alkyl-phenylketones  Hexoses  Butyrophenones  O-glycosyl compounds  Phenol ethers  Resorcinols  Benzoyl derivatives  Aryl alkyl ketones  Phenoxy compounds  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Oxanes  Vinylogous acids  Secondary alcohols  Oxacyclic compounds  Acetals  Polyols  Organic oxides  Hydrocarbon derivatives  Primary alcohols  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Flavonoid o-glycoside - 2'-hydroxy-dihydrochalcone - Linear 1,3-diarylpropanoid - Cinnamylphenol - Phenolic glycoside - Alkyl-phenylketone - Hexose monosaccharide - O-glycosyl compound - Glycosyl compound - Butyrophenone - Phenylketone - Aryl alkyl ketone - Aryl ketone - Benzoyl - Resorcinol - Phenoxy compound - Phenol ether - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Phenol - Benzenoid - Monocyclic benzene moiety - Monosaccharide - Oxane - Vinylogous acid - Secondary alcohol - Ketone - Acetal - Organoheterocyclic compound - Oxacycle - Polyol - Primary alcohol - Alcohol - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as flavonoid o-glycosides. These are compounds containing a carbohydrate moiety which is O-glycosidically linked to the 2-phenylchromen-4-one flavonoid backbone.
External Descriptors dihydrochalcones - Chalcones and dihydrochalcones

Associated Targets(Human)

SLC5A4 Tchem Solute carrier family 5 member 4 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC5A11 Tchem Sodium/myo-inositol cotransporter 2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC5A2 Tclin Sodium/glucose cotransporter 2 (21 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC5A3 Tbio Sodium/myo-inositol cotransporter (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC5A1 Tclin Sodium/glucose cotransporter 1 (18 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MFSD4B Tdark Sodium-dependent glucose transporter 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TYR Tclin Tyrosinase (717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EPHX2 Tchem Epoxide hydratase (3844 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC28A1 Tbio Sodium/nucleoside cotransporter 1 (13 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC28A2 Tchem Sodium/nucleoside cotransporter 2 (91 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC28A3 Tchem Solute carrier family 28 member 3 (29 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AKR1B10 Tchem Aldo-keto reductase family 1 member B10 (300 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC5A4 Tchem Low affinity sodium-glucose cotransporter (30 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc5a1 Sodium/glucose cotransporter 1 (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc5a2 Sodium/glucose cotransporter 2 (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
3T3-L1 (3664 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Intestine (514 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PNLIP Pancreatic triacylglycerol lipase (476 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one
INCHI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
InChIKey IOUVKUPGCMBWBT-QNDFHXLGSA-N
Smiles C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O
Isomeric SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O)O
WGK Germany 3
PubChem CID 6072
Molecular Weight 436.45
Beilstein 66621

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
A2517420 Certificate of Analysis Jan 09, 2025 P139206
A2517423 Certificate of Analysis Jan 09, 2025 P139206
A2517437 Certificate of Analysis Jan 09, 2025 P139206
A2517438 Certificate of Analysis Jan 09, 2025 P139206
C2412392 Certificate of Analysis Mar 06, 2024 P139206
C2412396 Certificate of Analysis Mar 06, 2024 P139206
C2412397 Certificate of Analysis Mar 06, 2024 P139206
J2209518 Certificate of Analysis Sep 22, 2022 P139206
J2209519 Certificate of Analysis Sep 22, 2022 P139206
J2209520 Certificate of Analysis Sep 22, 2022 P139206

Chemical and Physical Properties

Solubility Soluble in DMSO (100 mM), methanol, acetone, ethanol (100 mM), and water (partly).
Refractive Index 1.69
Melt Point(°C) 113-114°C
Molecular Weight 436.400 g/mol
XLogP3 1.200
Hydrogen Bond Donor Count 7
Hydrogen Bond Acceptor Count 10
Rotatable Bond Count 7
Exact Mass 436.137 Da
Monoisotopic Mass 436.137 Da
Topological Polar Surface Area 177.000 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 581.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 5
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (101023). 
2. Jing Zhang, Yali Song, Xia Hu, Zhen Zeng, Jie Hu, Tingting Zeng, Fang Geng, Di Wu.  (2023)  Nanoparticles loaded with phlorizin fabricate a fortified yogurt with antioxidant potential.  Food Bioscience,  54  (102849). 
3. Yang Liu, Jiali Lin, Tiantian Cheng, Yangjie Liu, Fuliang Han.  (2022)  Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells.  Foods,  11  (23): (3793). 
4. Zhang Hongzhen, Zhang Chenghua, Xiang Xiaolong, Zhang Qilun, Zhao Wei, Wei Guoyu, Hu Anlong.  (2022)  Uptake and transport of antibiotic kasugamycin in castor bean (Ricinus communis L.) seedlings.  Frontiers in Microbiology,  13   
5. Haoyu Zhou, Changzhong Liu, Sheng Geng.  (2021)  Laccase Catalyzed Oxidative Polymerization of Phloridzin: Polymer Characterization, Antioxidant Capacity and α-Glucosidase Inhibitory Activity.  Natural Product Communications,     
6. Lijuan Wang, Liji Huang, Nan Li, Junjun Miao, Wei Liu, Jiangyi Yu.  (2019)  Ameliorative effect of polydatin on hyperglycemia and renal injury in streptozotocin-induced diabetic rats.  CELLULAR AND MOLECULAR BIOLOGY,  65  (7):  
7. Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, Ying Zhang.  (2019)  Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells.  Food & Function,  10  (8): (5215-5227). 
8. Yurong Ma, Qingfeng Ban, Jingying Shi, Tiantian Dong, Cai-Zhong Jiang, Qingguo Wang.  (2019)  1-Methylcyclopropene (1-MCP), storage time, and shelf life and temperature affect phenolic compounds and antioxidant activity of ‘Jonagold’ apple.  POSTHARVEST BIOLOGY AND TECHNOLOGY,  150  (71). 
9. Yongsheng Chen, Jiangwei Liu, Sheng Geng, Yonglan Liu, Hanjun Ma, Jie Zheng, Benguo Liu, Guizhao Liang.  (2019)  Lipase-catalyzed synthesis mechanism of tri-acetylated phloridzin and its antiproliferative activity against HepG2 cancer cells.  FOOD CHEMISTRY,  277  (186). 
10. Benguo Liu, Jiangwei Liu, Chunling Zhang, Jiechao Liu, Zhonggao Jiao.  (2017)  Enzymatic preparation and antioxidant activity of the phloridzin oxidation product.  JOURNAL OF FOOD BIOCHEMISTRY,  42  (2): (e12475). 
11. Wang Qian-Wen, Liu Jia-Jia, Liu Xiong, Zha Hong-Wei, Ren Na.  (2014)  Purification of phloridzin from Lithocarpus polystachyus Rehd leaves using polymeric adsorbents functionalized with glucosamine and β-cyclodextrin.  CHEMICAL PAPERS,  68  (11): (1521-1531). 
12. Jie Wang, Zhiwei Lei, Yingjie Wen, Genlin Mao, Hanxiang Wu, Hanhong Xu.  (2014)  A Novel Fluorescent Conjugate Applicable To Visualize the Translocation of Glucose–Fipronil.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  62  (35): (8791–8798). 
13. Muhammad Abid, Saqib Jabbar, Tao Wu, Malik Muhammad Hashim, Bing Hu, Shicheng Lei, Xiaoxiong Zeng.  (2014)  Sonication enhances polyphenolic compounds, sugars, carotenoids and mineral elements of apple juice.  ULTRASONICS SONOCHEMISTRY,  21  (93). 
14. Xiaomeng Zhang, Xinquan Tian, Junyu Luo, Xiaoyang Wang, Shoupu He, Gaofei Sun, Ruidan Dong, Panhong Dai, Xiao Wang, Zhaoe Pan, Baojun Chen, Daowu Hu, Liru Wang, Baoyin Pang, Aishuang Xing, Guoyong Fu, Baoquan Wang, Jinjie Cui, Lei Ma, Xiongming Du.  (2025)  Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum.  PLANT JOURNAL,  121  (3): (e17248). 
15. Zhengming Qian, Qinggui Lei, Dan Tang, Guoying Tan, Qi Huang, Fucai Zhou, Wenhao Wang.  (2024)  Rapid and green quantification of phloridzin and trilobatin in Lithocarpus litseifolius (Hance) Chun (sweet tea) using an online pressurized liquid extraction high-performance liquid chromatography at equal absorption wavelength method.  Analytical Methods,  16  (16): (2513-2521). 

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