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Phloretin - ≥98%, high purity , CAS No.60-82-2, Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1

32 Citations COA COA
In stock
Item Number
P127748
Grouped product items
SKU Size
Availability
 Price Qty
P127748-250mg
250mg
3
$9.90
P127748-1g
1g
3
$19.90
P127748-5g
5g
3
$55.90
P127748-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$199.90
P127748-100g
100g
3
$559.90
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Dihydrochalcones flavonoid

View related series
AQP9 Inhibitor (1) ClC-3 Channel blocker (1) Endogenous Metabolite (959) GLUT (19) major facilitator superfamily domain containing 4B Inhibitor (2) Membrane Transporter (607) Membrane Transporter/Ion Channel (1822) Metabolic Enzyme/Protease (4860) Metabolite (5307) SGLT (27) Sodium-dependent vitamin C transporter 1 Inhibitor (1) TAS2R14 Agonist (20) TAS2R39 Agonist (11)

Basic Description

Synonyms KBio1_001373 | LMPK12120525 | P1966 | PHLORETIN [MI] | Tox21_501012 | Asebogenol | Lopac-P-7912 | 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone | 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone | beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiop
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Phloretin is an inhibitor of calcium channel protein, MCT1, MCT2, and PKC. It is the major polyphenol found in apple.Dihydrochalcones flavonoid. GLUT inhibitor. Active phlorizin metabolite. Blocks L-type Ca 2+ channels. Activates Ca 2+ -activated K + chan
Storage Temp Store at 2-8°C,Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST, CHANNEL BLOCKER, INHIBITOR
Mechanism of action Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
A calcium channel protein inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Linear 1,3-diarylpropanoids
Subclass Chalcones and dihydrochalcones
Intermediate Tree Nodes Not available
Direct Parent 2'-Hydroxy-dihydrochalcones
Alternative Parents Cinnamylphenols  Alkyl-phenylketones  Butyrophenones  Acylphloroglucinols and derivatives  Benzoyl derivatives  Aryl alkyl ketones  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Vinylogous acids  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents 2'-hydroxy-dihydrochalcone - Cinnamylphenol - Alkyl-phenylketone - Acylphloroglucinol derivative - Butyrophenone - Benzenetriol - Phloroglucinol derivative - Phenylketone - Aryl alkyl ketone - Aryl ketone - Benzoyl - Phenol - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Vinylogous acid - Ketone - Polyol - Organic oxide - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as 2'-hydroxy-dihydrochalcones. These are organic compounds containing dihydrochalcone skeleton that carries a hydroxyl group at the 2'-position.
External Descriptors a small molecule

Associated Targets(Human)

SLC23A1 Tchem Solute carrier family 23 member 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TAS2R39 Tchem Taste receptor type 2 member 39 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TAS2R14 Tchem Taste receptor type 2 member 14 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
AQP9 Tbio Aquaporin-9 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CLCN3 Tchem H(+)/Cl(-) exchange transporter 3 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MFSD4B Tdark Sodium-dependent glucose transporter 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TYR Tclin Tyrosinase (717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC2A1 Tchem Glucose transporter (14755 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 (435 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATM Tchem Serine-protein kinase ATM (4198 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HaCaT (4069 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC28A3 Tchem Solute carrier family 28 member 3 (29 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

blaZ Beta-lactamase (285 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Alpha-chymotrypsin (819 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ttr Transthyretin (14 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Abcc1 Multidrug resistance-associated protein 1 (42 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc5a1 Sodium/glucose cotransporter 1 (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc5a2 Sodium/glucose cotransporter 2 (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Listeria monocytogenes (2626 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus cereus (7522 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
3T3-L1 (3664 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vero (26788 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
fabH 3-oxoacyl-[acyl-carrier-protein] synthase 3 (47 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
norA Quinolone resistance protein norA (2171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Protease (18 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PNLIP Pancreatic triacylglycerol lipase (476 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504750814
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504750814
IUPAC Name 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
INCHI InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChIKey VGEREEWJJVICBM-UHFFFAOYSA-N
Smiles C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
Isomeric SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
WGK Germany 3
Molecular Weight 274.27
Beilstein 1887240
Reaxy-Rn 1887240
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1887240&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number Certificate Type Date Item
E2529149 Certificate of Analysis Jun 05, 2025 P127748
B2514035 Certificate of Analysis Feb 21, 2025 P127748
J2210680 Certificate of Analysis Aug 14, 2024 P127748
H2405013 Certificate of Analysis Aug 13, 2024 P127748
F2503518 Certificate of Analysis Jul 12, 2024 P127748
E2224117 Certificate of Analysis Mar 20, 2024 P127748
H2124477 Certificate of Analysis Jun 07, 2023 P127748
H2124478 Certificate of Analysis Jun 07, 2023 P127748
A2403030 Certificate of Analysis Jul 23, 2022 P127748
J2210662 Certificate of Analysis Jul 23, 2022 P127748
J2210681 Certificate of Analysis Jul 23, 2022 P127748
J2210661 Certificate of Analysis Jul 23, 2022 P127748
C2419221 Certificate of Analysis Jul 23, 2022 P127748
E2224255 Certificate of Analysis Mar 21, 2022 P127748
E2224260 Certificate of Analysis Mar 21, 2022 P127748

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Chemical and Physical Properties

Solubility Soluble in ethanol, methanol, acetone, hot glacial acetic acid, alkalies, benzene (sparingly soluble), chloroform (sparingly soluble), and DMSO. Insoluble in water, and ether.
Sensitivity light and air and heat sensitive
Melt Point(°C) 262°C
Molecular Weight 274.270 g/mol
XLogP3 2.600
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 4
Exact Mass 274.084 Da
Monoisotopic Mass 274.084 Da
Topological Polar Surface Area 98.000 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 312.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu.  (2024)  Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity.  MOLECULES,  29  (1): (66). 
2. Yu Hu, Hui Guo, Shuai Cheng, Junpeng Sun, Jiaqun Du, Xiaobang Liu, Ying Xiong, Liqing Chen, Chang Liu, Chao Wu, He Tian.  (2023)  Functionalized Cerium Dioxide Nanoparticles with Antioxidative Neuroprotection for Alzheimer’s Disease.  International Journal of Nanomedicine,     
3. Hong Hu, Liang Chen, Ying Huang, Kunping Wang, Xi Bai, Hongbin Pan.  (2023)  CUT&tag-seq analysis of heat stress response in broiler liver provides novel insights into the improved thermotolerance by dietary phloretin.  ANNALS OF AGRICULTURAL SCIENCE,  68  (12). 
4. Wang Jie, Jia Jingyu, Sun Jiaju, Pang Xinyue, Li Bairu, Yuan Jiangfeng, Chen Enyan, Li Xin.  (2023)  Trypsin preservation: CsUGT91C1 regulates Trilobatin Biosynthesis in Cucumis sativus during Storage.  PLANT GROWTH REGULATION,  100  (3): (633-646). 
5. Yang Liu, Jiali Lin, Tiantian Cheng, Yangjie Liu, Fuliang Han.  (2022)  Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells.  Foods,  11  (23): (3793). 
6. Mile Li, Mengyi Wang, Shuhui Hu, Jing Sun, Mingqiang Zhu, Yongsheng Ni, Jianlong Wang.  (2022)  Advanced Coatings with Antioxidant and Antibacterial Activity for Kumquat Preservation.  Foods,  11  (15): (2363). 
7. Yingqiao Li, Zhiru Zou, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury.  DRUG DELIVERY,  29  (1): (2498-2512). 
8. Zhang Guorong, Wang Qin, Tao Wanyin, Jiang Wei, Elinav Eran, Wang Yucai, Zhu Shu.  (2022)  Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis.  Nature Biomedical Engineering,  6  (7): (867-881). 
9. Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui.  (2022)  O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing.  ANALYTICAL CHEMISTRY,  94  (26): (9306–9315). 
10. Zhiru Zou, Shan Wen, Yingqiao Li, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Novel lactoferrin-functionalized manganese-doped silica hollow mesoporous nanoparticles loaded with resveratrol for the treatment of ischemic stroke.  Materials Today Advances,  15  (100262). 
11. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua.  (2022)  Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats.  Journal of Ocean University of China,  21  (3): (782-788). 
12. Wu Wanbao, Bo Yiyang, Li Deping, Liang Yihong, Zhang Jichuan, Cao Miaomiao, Guo Ruitian, Zhu Zhenye, Ci Lijie, Li Mingyu, Zhang Jiaheng.  (2022)  Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte.  Nano-Micro Letters,  14  (1): (1-14). 
13. Xue Jiang, Xiaoyao Liu, Qi Yu, Wenwen Shen, Xifan Mei, He Tian, Chao Wu.  (2022)  Functional resveratrol-biodegradable manganese doped silica nanoparticles for the spinal cord injury treatment.  Materials Today Bio,  13  (100177). 
14. Xiaona Hu, Ziruo Zhou, Lijun Han, Shujing Li, Wei Zhou.  (2020)  Preparation and characterization of phloretin by complexation with cyclodextrins.  NEW JOURNAL OF CHEMISTRY,  44  (14): (5218-5223). 
15. Zerong Li, Wenmei Qiao, Chenghao Wang, Heqiao Wang, Mengchao Ma, Xinyu Han, Jingling Tang.  (2020)  DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment.  DRUG DELIVERY,     
16. Zenghui Xie, Yanli Chen, Lanyun Zhang, Xujia Hu.  (2020)  Magnetic molecularly imprinted polymer combined with high performance liquid chromatography for selective extraction and determination of the metabolic content of quercetin in rat plasma.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,  31  (1): (53-71). 
17. Dandan Wang, Liangxiao Zhang, Yueqing Xu, Xin Qi, Xuefang Wang, Xiupin Wang, Qi Zhang, Peiwu Li.  (2019)  Optimization of an Ultrasound-Assisted Extraction for Simultaneous Determination of Antioxidants in Sesame with Response Surface Methodology.  Antioxidants,  8  (8): (321). 
18. Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, Ying Zhang.  (2019)  Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells.  Food & Function,  10  (8): (5215-5227). 
19. Yin Ying, Cheng Jiang, Meiling Zhang, Jiye Jin, Shuyu Ge, Xiaodong Wang.  (2019)  Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model.  Aging-US,  11  (9): ( 2822–2835). 
20. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong.  (2019)  Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity.  LWT-FOOD SCIENCE AND TECHNOLOGY,  107  (25). 
21. Hai-Na Yu, Xin-Yan Liu, Shuai Gao, Bin Sun, Hong-Bo Zheng, Mei Ji, Ai-Xia Cheng, Hong-Xiang Lou.  (2018)  Structural and biochemical characterization of the plant type III polyketide synthases of the liverwort Marchantia paleacea.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,  125  (95). 
22. Jiming Wu, Jinghan Li, Jin Zhang, Xinyue Hu, Dahong Yao, Liang Ma, Liang Ouyang, Xinhui Pan, Jian Huang, Ruichao Lin, Jinhui Wang.  (2016)  In silico identification and experimental validation of diuresis compounds from Euphorbia lathyris for potential UT-B inhibitors.  Journal of the Taiwan Institute of Chemical Engineers,  60  (124). 
23. Siyang Chen, Wenxiu Zhu, Yiqun Zhan, Xiaodong Xia.  (2024)  Antibacterial Activity of Phloretin Against Vibrio parahaemolyticus and Its Application in Seafood.  Foods,  13  (22): (3537). 
24. Cong Liu, Weihua Liu, Qianqian Wang, Chun Wang, Qiuhua Wu.  (2025)  Construction of novel hyper-crosslinked polymers with adjustable hydrophilicity for efficient extraction of nitroimidazoles.  JOURNAL OF CHROMATOGRAPHY A,  1743  (465702). 
25. Chang Tang, Rui Tong, Guoqing Deng, Jing Yang, Yi Zhang, Zhifeng Cai.  (2024)  Fluorescent carbon dots for highly sensitive diosmetin sensing.  MICROCHEMICAL JOURNAL,  200  (110362). 
26. Xiaomeng Zhang, Xinquan Tian, Junyu Luo, Xiaoyang Wang, Shoupu He, Gaofei Sun, Ruidan Dong, Panhong Dai, Xiao Wang, Zhaoe Pan, Baojun Chen, Daowu Hu, Liru Wang, Baoyin Pang, Aishuang Xing, Guoyong Fu, Baoquan Wang, Jinjie Cui, Lei Ma, Xiongming Du.  (2025)  Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum.  PLANT JOURNAL,  121  (3): (e17248). 
27. Jiaqi Wen, Shuling Chen, Le Deng, Xinru Chen, Xiaoyu Jiang, Xing Hu, Deming Gong, Guowen Zhang.  (2024)  Inhibitiory mechanism of phloretin on xanthine oxidase and its synergistic effect with allopurinol and febuxostat.  Food Bioscience,  61  (104720). 
28. Xia Yang, Yun Wang, Yan Sun, Jiali Guo, Zhaojun Geng, Bingyao Wei, Peiqin Li, Guanghui Tang.  (2025)  Integrated transcriptomics and metabolomics revealed the role of the flavonoid pathway in the resistance of Zanthoxylum bungeanum against leaf rust.  SCIENTIA HORTICULTURAE,  341  (113990). 
29. Yongsong Zhang, Na Xia, Zhenzhen Ding, Jingjing Song, Yanan Zhang, Cao Li, Xuesong Huang, Zuoshan Feng.  (2025)  Preparation, structural changes and functional properties of the covalent complexes of almond protein and phloretin.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (139322). 
30. Yushi Wei, Jianmei Wu, Xi Peng, Xing Hu, Deming Gong, Guowen Zhang.  (2024)  Protein glycosylation inhibitory effects and mechanisms of phloretin and phlorizin.  Food Bioscience,  61  (104971). 
31. Jiawei Li, Chengyu Hong, Hao Zhang, Jiaqi Zhang, Ruixue Zhai, Bin Fei, Chao Zhou.  (2024)  Sustainable, transparent, strong toughness, UV resistance, and anti-corrosion properties of cashew shell oil-based waterborne polyurethane network derived from phloretin and sorbitan monooleate-based siloxane.  CHEMICAL ENGINEERING JOURNAL,  490  (151506). 
32. Zhou Zhixin, Zhou Cheng, Liu Jia, Yuan Ye, Yao Chundong, Liu Miaodeng, Deng Lixue, Sun Jia, Chen Zuoyu, Wang Lin, Wang Zheng.  (2024)  Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-18). 

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