Arsenic Benzene Oxide (Pao) reduced the viability and sustainability of Setaria Chinensis. In the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether) N, N, N ′ , N ′ -) , it has the ability to stimulate Cyclosporin a-sensitive transformation. It ca
Storage Temp
Room temperature
Shipped In
Normal
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of phosphatidylinositol 4-kinase alpha
Product Description
Phenylarsine Oxide (PAO) is a membrane-permeable protein-tyrosine phosphatase (PTPase) inhibitor with no effect on tyrosine kinase. It inhibits the internalization of cell surface receptors. Phenylarsine Oxide (PAO) is very useful in the study of tyrosine phosphorylation events and the mechanisms that inhibit or block tyrosine phosphorylation. One report applied PAO and TNF to human myeloid cells (ML-1a) to study TNF-dependent NFκB activation. Phenylarsine Oxide (PAO) has been reported to stimulate 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates Lck (lymphocyte-specific protein tyrosine kinase). Since PAO is also an inhibitor of caspases and nuclear apoptotic events, it is useful for the study of apoptosis.
This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
External Descriptors
arsine oxides
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
H2202360