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[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2, CAS No.213130-17-7
Selective nociceptin receptor agonist
Basic Description
Product Name
[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2, CAS No.213130-17-7
Biochemical and Physiological Mechanisms
Potent agonist of the nociceptin (ORL1) receptor, demonstrated bothin vitroandin vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2= 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).
Sequence
FGGFTGARKSARK(Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH2-NH), Lys-13 = C-terminal amide)
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organic Polymers
Class
Polypeptides
Subclass
Not available
Intermediate Tree Nodes
Not available
Direct Parent
Polypeptides
Alternative Parents
Peptides Phenylalanine and derivatives N-acyl-alpha amino acids and derivatives Serine and derivatives Alpha amino acid amides Alanine and derivatives Amphetamines and derivatives Aralkylamines N-acyl amines Secondary carboxylic acid amides Secondary alcohols Primary carboxylic acid amides Guanidines Propargyl-type 1,3-dipolar organic compounds Carboximidamides Dialkylamines Carbonyl compounds Monoalkylamines Primary alcohols Organic oxides Hydrocarbon derivatives
Molecular Framework
Aromatic homomonocyclic compounds
Substituents
Polypeptide - Alpha peptide - Phenylalanine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Serine or derivatives - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Aralkylamine - Fatty acyl - Monocyclic benzene moiety - Fatty amide - Benzenoid - N-acyl-amine - Amino acid or derivatives - Carboxamide group - Guanidine - Secondary carboxylic acid amide - Primary carboxylic acid amide - Secondary alcohol - Secondary amine - Organic 1,3-dipolar compound - Carboxylic acid derivative - Secondary aliphatic amine - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Primary alcohol - Primary amine - Organic nitrogen compound - Carbonyl group - Amine - Hydrocarbon derivative - Alcohol - Organic oxygen compound - Primary aliphatic amine - Organooxygen compound - Organic oxide - Organonitrogen compound - Aromatic homomonocyclic compound
Description
This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Storage and Shipping
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
CAS
213130-17-7
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
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