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PHD-1-IN-1 - 99%, high purity , CAS No.2009343-14-8

COA

Grade & Purity:

≥99%

Cas Number: 2009343-14-8
Molecular Weight: 220.23

In stock

Item Number

P646307

Grouped product items
SKU	Size	Availability	Price
P646307-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$222.90
P646307-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$355.90
P646307-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$712.90
P646307-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,139.90

View related series

Glucose Metabolism (1943) HIF/HIF Prolyl-Hydroxylase (128) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC 50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe 2+ ion and induces the formation of an “Arg367-out” pocke
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC 50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe 2+ ion and induces the formation of an “Arg367-out” pocket In Vivo PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a C max of 0.8 μM, a AUC of 176 ng•h/mL, K p,uu of 1.11 and B/P of 0.95 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL6 mice Dosage: 3 mg/kg (p.o.) or 0.5 mg/kg (i.v.) (Pharmacokinetic Analysis) Administration: PO or IV Result: Had a C max of 0.8 μM, a AUC of 176 ng•h/mL, K p,uu of 1.11 and B/P of 0.95. Form:Solid IC50& Target:IC50: 0.034 μM (PHD-1)

Names and Identifiers

Smiles	N#CC1=CC=C(C2=CC=CC3=NC=NN23)C=C1
Molecular Weight	220.23

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