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PF-CBP1 HCl - 96%, high purity , CAS No.2070014-93-4

COA

Grade & Purity:

≥96%

Cas Number: 2070014-93-4
Molecular Weight: 525.08
PubChem CID: 119081416
PubChem SID: 504772912

In stock

Item Number

P413931

Grouped product items
SKU	Size	Availability	Price
P413931-5mg	5mg	2	$48.90
P413931-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$73.90
P413931-25mg	25mg	2	$147.90
P413931-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$246.90
P413931-100mg	100mg	2	$444.90
P413931-250mg	250mg	2	$1,001.90

Epigenetic Reader Domain Inhibitors

View related series

Epigenetic Reader Domain (314) Epigenetics (1496) Histone Acetyltransferase (79) Histone Modification (1379)

Basic Description

Synonyms	4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride \| 5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole hydrochloride
Specifications & Purity	≥96%
Biochemical and Physiological Mechanisms	PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information PF-CBP1 HCl PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP) .It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. Targets CREBBP (Cell-free assay); p300/CBP (Cell-free assay) 125nM; 363nM In vitro PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson\'s disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high. Cell Research(from reference) Cell lines：mouse J774 macrophage-like cell line Concentrations：0.1-10\xa0μM Incubation Time：30min

Names and Identifiers

Pubchem Sid	504772912
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772912
IUPAC Name	4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-propoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholine;hydrochloride
INCHI	InChI=1S/C29H36N4O3.ClH/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32;/h5-6,8-11,20H,4,7,12-19H2,1-3H3;1H
InChIKey	HFOZCHHWLMTUTP-UHFFFAOYSA-N
Smiles	CCCOC1=CC=C(C=C1)CCC2=NC3=C(N2CCN4CCOCC4)C=CC(=C3)C5=C(ON=C5C)C.Cl
PubChem CID	119081416
Molecular Weight	525.08

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

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Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
H2222121	Certificate of Analysis	Jun 09, 2025	P413931
H2222123	Certificate of Analysis	Jun 09, 2025	P413931
H2222122	Certificate of Analysis	Jun 09, 2025	P413931
H2222124	Certificate of Analysis	Jun 09, 2025	P413931
L2410147	Certificate of Analysis	Jun 13, 2022	P413931

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (190.44 mM); Ethanol: 100 mg/mL (190.44 mM); Water: Insoluble;
Sensitivity	Moisture sensitive.
Molecular Weight	525.100 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	524.255 Da
Monoisotopic Mass	524.255 Da
Topological Polar Surface Area	65.600 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	654.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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