Skip to the beginning of the images gallery

PF 429242 dihydrochloride - ≥97%(HPLC), high purity , CAS No.2248666-66-0

COA

Grade & Purity:

≥97%(HPLC)

Cas Number: 2248666-66-0
Molecular Weight: 482.49
PubChem CID: 90488837
PubChem SID: 504772602

In stock

Item Number

P288702

Grouped product items
SKU	Size	Availability	Price
P288702-5mg	5mg	3	$103.90
P288702-10mg	10mg	2	$182.90
P288702-25mg	25mg	1	$365.90
P288702-50mg	50mg	2	$652.90
P288702-100mg	100mg	2	$1,149.90

Competitive inhibitor of SREBP site 1 protease

View related series

Anti-infection (2803) Fatty Acid Synthase (FASN) (41) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) Virus (1811) Virus Protease (105)

Basic Description

Synonyms	4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide dihydrochloride
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50= 0.175μM). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC50= 0.53μM).
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Benzamides
Alternative Parents	Phenylmethylamines Phenoxy compounds Methoxybenzenes Anisoles Benzylamines Benzoyl derivatives Alkyl aryl ethers Aralkylamines Tertiary carboxylic acid amides Pyrrolidines Trialkylamines Amino acids and derivatives Dialkylamines Azacyclic compounds Hydrocarbon derivatives Organic oxides Hydrochlorides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzamide - Anisole - Benzoyl - Benzylamine - Phenol ether - Phenylmethylamine - Methoxybenzene - Phenoxy compound - Aralkylamine - Alkyl aryl ether - Tertiary carboxylic acid amide - Pyrrolidine - Amino acid or derivatives - Tertiary aliphatic amine - Tertiary amine - Carboxamide group - Azacycle - Organoheterocyclic compound - Secondary amine - Carboxylic acid derivative - Secondary aliphatic amine - Ether - Organic oxide - Organic oxygen compound - Hydrochloride - Hydrocarbon derivative - Amine - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzamides. These are organic compounds containing a carboxamido substituent attached to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504772602
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772602
IUPAC Name	4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide;dihydrochloride
INCHI	InChI=1S/C25H35N3O2.2ClH/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3;;/h6-13,23,26H,4-5,14-19H2,1-3H3;2*1H/t23-;;/m1../s1
InChIKey	GSUZWFZKTIOWTI-MQWQBNKOSA-N
Smiles	CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)C3CCNC3.Cl.Cl
Isomeric SMILES	CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)[C@@H]3CCNC3.Cl.Cl
Alternate CAS	947303-87-9
PubChem CID	90488837
Molecular Weight	482.49

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
H2203543	Certificate of Analysis	May 12, 2025	P288702
H2203541	Certificate of Analysis	May 12, 2025	P288702
H2203540	Certificate of Analysis	May 12, 2025	P288702
H2203539	Certificate of Analysis	May 12, 2025	P288702
H2203542	Certificate of Analysis	May 12, 2025	P288702

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 24.12, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 24.12, Max Conc. mM: 50
Molecular Weight	482.500 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	10
Exact Mass	481.226 Da
Monoisotopic Mass	481.226 Da
Topological Polar Surface Area	44.800 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	503.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration