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PF-05198007 - 10mM in DMSO, high purity , CAS No.1235406-19-5(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1235406-19-5(DMSO)
Molecular Weight: 533.91

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Item Number

P655824

Grouped product items
SKU	Size	Availability	Price	Qty
P655824-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$217.90

View related series

Compound libraries (12325) Membrane Transporter/Ion Channel (1822) Sodium Channel (211)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	PF-05198007 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PF-05198007 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771 In Vitro PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current indicating that the major TTX-S conductance is carried through Na v 1.7 channels in small-diameter mouse DRG neurons (n = 35). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-05198007 (1 or 10 mg/kg, orally) reduces the capsaicin flare response in WT, but not Na v 1.7Na v 1.8Cre mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult Male C57Bl/6J Wild type (WT) and Na v 1.7Na v 1.8Cre mice . Dosage: 1 or 10 mg/kg. Administration: Orally once. Result: Reduced the flare response to capsaicin for the duration of the observation period (55 mins; Vehicle; 4930 ± 751 versus 1 and 10 mg/kg 1967 ± 472 and 2265 ± 382, respectively (n = 7), AUC, p < 0.05). IC50& Target:Nav1.7

Names and Identifiers

Smiles	O=S(C1=CC(Cl)=C(OC2=CC=C(C(F)(F)F)C=C2C3=CNN=C3N)C=C1F)(NC4=CSC=N4)=O
Molecular Weight	533.91

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