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PEPA - 98%, high purity , CAS No.141286-78-4

    Grade & Purity:
  • ≥98%
In stock
Item Number
P335717
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Availability
Price Qty
P335717-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$141.90
P335717-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$616.90

an allosteric potentiator of AMPA desensitization

Basic Description

Synonyms 2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide | J-007478 | Lopac-D-8941 | NCGC00094134-02 | AI3-05522 | 8S4PR7A8JS | 4-(2-(phenylsulfonylamino)ethylthio)-2,6-difluorophenoxyacetamide | CCG-204884 | DTXSID60424960 | HMS3262O22 | SR-0100
Specifications & Purity ≥98%
Storage Temp Room temperature
Shipped In Normal
Product Description

PEPA is an allosteric potentiator of AMPA desensitization. PEPA decreases the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by Glu with splic variant and subunit selectivity. PEPA enhances post-ischemic memory impairment in rats post i.v. administration. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. PEPA is an activator of GluR.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzenesulfonamides
Intermediate Tree Nodes Not available
Direct Parent Benzenesulfonamides
Alternative Parents Benzenesulfonyl compounds  Thiophenol ethers  Phenol ethers  Phenoxy compounds  Alkylarylthioethers  Fluorobenzenes  Alkyl aryl ethers  Organosulfonamides  Aryl fluorides  Aminosulfonyl compounds  Primary carboxylic acid amides  Sulfenyl compounds  Organonitrogen compounds  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Benzenesulfonamide - Benzenesulfonyl group - Phenoxy compound - Aryl thioether - Phenol ether - Thiophenol ether - Alkyl aryl ether - Alkylarylthioether - Halobenzene - Fluorobenzene - Aryl fluoride - Aryl halide - Organosulfonic acid amide - Aminosulfonyl compound - Organic sulfonic acid or derivatives - Sulfonyl - Organosulfonic acid or derivatives - Primary carboxylic acid amide - Carboxamide group - Sulfenyl compound - Carboxylic acid derivative - Ether - Thioether - Organosulfur compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors Not available

Product Properties

pKa pKₐ: 10.44 (Predicted)

Associated Targets(Human)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIA3 Tclin Glutamate receptor ionotropic, AMPA 3 (127 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIA1 Tclin Glutamate receptor ionotropic, AMPA 1 (277 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SH-SY5Y (11521 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIA3 Tclin Glutamate receptor AMPA 2/3 (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gria2 Glutamate receptor AMPA 1/2 (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA 2/3 (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-[4-[2-(benzenesulfonamido)ethylsulfanyl]-2,6-difluorophenoxy]acetamide
INCHI InChI=1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)
InChIKey GTACSIONMHMRPD-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
Isomeric SMILES C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
WGK Germany 3
PubChem CID 6603828
Molecular Weight 402.44

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Soluble in DMSO (100 mM), and ethanol (25 mM).
Refractive Index n20D1.62 (Predicted)
Boil Point(°C) ~617.6° C at 760 mmHg (Predicted)
Melt Point(°C) 240.99° C (Predicted)
Molecular Weight 402.400 g/mol
XLogP3 2.200
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 9
Exact Mass 402.052 Da
Monoisotopic Mass 402.052 Da
Topological Polar Surface Area 132.000 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 541.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Zhu Sining, Wan Haitao, Yan Zhibo, Xi Chen, Zhang Yuzhuo, Zhang Fan.  (2023)  Synthesis and characterization of epoxy resin-based ion-imprinted polymer for selective removal of copper ions.  KOREAN JOURNAL OF CHEMICAL ENGINEERING,  40  (9): (2356-2364). 
2. Hua Zhou, Liangdong Ye, Dongming Chen, Ziwei Li, Shanrong Li, Dacheng Li, Zhiyi Huang, Zhouqiao Wei, Shaorong Lu.  (2023)  A bio-based compatibilizer for improved interfacial compatibility in thermally conductive and electrically insulating graphite/high density poly(ethylene) composites.  JOURNAL OF VINYL & ADDITIVE TECHNOLOGY,  29  (6): (991-1001). 
3. Sining Zhu, Chen Xi, Yuzhuo Zhang, Fan Zhang.  (2022)  Preparation and Characterization of Cadmium(II)-Ion-Imprinted Composites Based on Epoxy Resin.  ACS Applied Polymer Materials,  (12): (9284–9293). 
4. Yufei Liu, Yikai Zhan, Min He, Chengjun Xiao, Shan Liu, Shuhao Qin, Jie Yu.  (2022)  Amino-functionalized carbon fiber/polyamide 6 composites with enhanced interfacial and mechanical properties.  Journal of Materials Research and Technology-JMR&T,  20  (3229). 
5. Xiaofei Yan, Jie Fang, Jianjun Gu, Chenkai Zhu, Dongming Qi.  (2022)  Flame Retardancy, Thermal and Mechanical Properties of Novel Intumescent Flame Retardant/MXene/Poly(Vinyl Alcohol) Nanocomposites.  Nanomaterials,  12  (3): (477). 
6. Qian Wang, Huanshun Yin, Jia Ding, Yunlei Zhou, Shiyun Ai.  (2021)  WS2/Bi/BiOBr Nanostructures for Photoelectrochemical Sensing of 5-Formyluracil-2′-deoxyuridine-5′-triphosphate through Hemin/G-Quadruplex Double Signal Amplification.  ACS Applied Nano Materials,  (9): (8998–9007). 
7. Tianqi Chen, Mengjin Chen, Zhan Chen, Chaoyang Fu.  (2021)  Comprehensive investigation of modified polyethyleneimine as an efficient polymeric corrosion inhibitor in neutral medium: Synthesis, experimental and theoretical assessments.  JOURNAL OF MOLECULAR LIQUIDS,  339  (116803). 
8. Hongyang Wang, Shuai Lan, Yu Zhang, Lu Zhang, Dandan Jia, Weiguo Zhang, Chun Liu, Lei Cao, Dongjun Wang.  (2021)  Unique Property of Nontraditional Intrinsic Luminescence in the Transforming of Solution-Hydrogel-Solid and Its Applications.  MACROMOLECULAR CHEMISTRY AND PHYSICS,  222  (13): (2100070). 
9. Li Lao, Kuo Liu, Li Ren, Jinhong Yu, Jingzhen Cheng, Yuqi Li, Shaorong Lu.  (2021)  Improving Corrosion Protection and Friction Resistance of Q235 Steel by Combining Noncovalent Action and Rotating Coating Method.  ACS Omega,  (11): (7434–7443). 
10. Binglin Wang, Jiaxin Li, Xuejun Lai, Hongqiang Li, Yishen Chen, Xingrong Zeng.  (2021)  Synthesis of a novel N-alkoxyamine containing macromolecular intumescent flame retardant and its synergism in flame-retarding polypropylene.  POLYMERS FOR ADVANCED TECHNOLOGIES,  32  (6): (2452-2464). 
11. Gaofeng Zeng, Weiwei Zhang, Xin Zhang, Wenchao Zhang, Jianxin Du, Jiyu He, Rongjie Yang.  (2020)  Study on flame retardancy of APP/PEPA/MoO3 synergism in vinyl ester resins.  JOURNAL OF APPLIED POLYMER SCIENCE,  137  (35): (49026). 
12. Yanchao Xu, Dongxue Guo, Tong Li, Yirong Xiao, Liguo Shen, Renjie Li, Yang Jiao, Hongjun Lin.  (2020)  Manipulating the mussel-inspired co-deposition of tannic acid and amine for fabrication of nanofiltration membranes with an enhanced separation performance.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  565  (23). 
13. Xia Wang, Wulan Zeng, Hongyan Zhang, Dan Li, Hongjing Tian, Xiude Hu, Qian Wu, Chunling Xin, Xiaoyu Cao, Wenjing Liu.  (2019)  The dynamic CO2 adsorption of polyethylene polyamine-loaded MCM-41 before and after methoxypolyethylene glycol codispersion.  RSC Advances,  (46): (27050-27059). 
14. Yuyuan Chen, Zhenzhen Wang, Xiaoli Hao, Fenglan Li, Yanjie Zheng, Jianzhong Zhang, Xinhua Lin, Shaohuang Weng.  (2019)  Selective and sensitive fluorescent monitoring of acid phosphatase (ACP) activity under neutral conditions through the ACP enzymatic catalysis of dopamine as a new substrate to polydopamine.  SENSORS AND ACTUATORS B-CHEMICAL,  297  (126784). 
15. Jianzhong Zhang, Yuyuan Chen, Zongfu Zheng, Zhenzhen Wang, Yanjie Zheng, Xinhua Lin, Shaohuang Weng.  (2019)  Fluorescence sensing of tyrosinase activity based on amine rich carbon dots through direct interaction in a homogeneous system: detection mechanism and application.  RSC Advances,  (35): (20029-20034). 
16. Fan-Ning Meng, Meng-Qian Zhang, Kai Ding, Ting Zhang, Yong-Kuan Gong.  (2018)  Cell membrane mimetic PVDF microfiltration membrane with enhanced antifouling and separation performance for oil/water mixtures.  Journal of Materials Chemistry A,  (7): (3231-3241). 
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18. Chengsheng Gui, Xiaoqing Liu, Di Wu, Tuo Zhou, Guyue Wang, Jin Zhu.  (2012)  Preparation of a New Type of Polyamidoamine and Its Application for Soy Flour-Based Adhesives.  JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY,  90  (2): (265-272). 
19. Xia Wang, Wulan Zeng, Peidan Hu, Shengxin Liu, Yuechao Lin, Zhaowen He, Chunling Xin, Xiangjun Kong, Jinghan Xu.  (2024)  Effect of Additives on CO2 Adsorption of Polyethylene Polyamine-Loaded MCM-41.  MOLECULES,  29  (5): (1006). 
20. Wanyi Zhang, Chenyu Zhou, Junshu Wang, Hanbo Wang, Xingguang Su.  (2025)  Ratiometric fluorescence/colorimetric dual-mode detection of tertiary butylhydroquinone in edible oils based on copper‑cerium oxide nanozyme and nitrogen-doped carbon dots.  FOOD CHEMISTRY,    (143517). 

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