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Peficitinib (ASP015K) - 98%, high purity , CAS No.944118-01-8, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 944118-01-8
Molecular Weight: 326.39
PubChem CID: 57928403

In stock

Item Number

P413804

Grouped product items
SKU	Size	Availability	Price
P413804-5mg	5mg	3	$249.90
P413804-10mg	10mg	3	$408.90
P413804-25mg	25mg	2	$717.90
P413804-50mg	50mg	2	$1,232.90
P413804-100mg	100mg	2	$2,059.90

JAK2 Selective Inhibitors

View related series

Epigenetics (1496) Histone Modification (1379) JAK (149) JAK/STAT Signaling (507) Janus kinase 1 Inhibitor (52) Janus kinase 2 Inhibitor (72) Janus kinase 3 Inhibitor (54) Non-receptor Tyrosine Kinase (643) Protein Tyrosine Kinase/RTK (1314) Stem Cell/Wnt (1019) tyrosine kinase 2 Inhibitor (39)

Basic Description

Synonyms	4-(((1R,2s,3S,5s,7s)-5-hydroxyadamantan-2-yl)amino)-1H-pyrrolo(2,3-b)pyridine-5-carboxamide \| 1H-Pyrrolo(2,3-b)pyridine-5-carboxamide, 4-((5-hydroxytricyclo(3.3.1.13,7)dec-2-yl)amino)-, stereoisomer \| GTPL8315 \| AMY42225 \| 9T6 \| PEFICITINIB [INN] \| JNJ-54
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2
Product Description	Information Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailableJAKinhibitor. Phase 3. Targets JAK In vitro ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). In vivo In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrrolopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrrolopyridines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Pyrrolopyridines
Alternative Parents	Pyridinecarboxamides Secondary alkylarylamines Aminopyridines and derivatives Vinylogous amides Tertiary alcohols Pyrroles Heteroaromatic compounds Primary carboxylic acid amides Cyclic alcohols and derivatives Amino acids and derivatives Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyrrolopyridine - Pyridine carboxylic acid or derivatives - Pyridinecarboxamide - Secondary aliphatic/aromatic amine - Aminopyridine - Pyridine - Heteroaromatic compound - Vinylogous amide - Tertiary alcohol - Pyrrole - Cyclic alcohol - Primary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Azacycle - Secondary amine - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyrrolopyridines. These are compounds containing a pyrrolopyridine moiety, which consists of a pyrrole ring fused to a pyridine. Pyrrole is 5-membered ring consisting of four carbon atoms and one nitrogen atom. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 (2 Activities)

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 (1 Activities)

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK1 Tclin Tyrosine-protein kinase JAK1 (2 Activities)

Discover Target: JAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 (2 Activities)

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[[(1S,3R)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
INCHI	InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10-,11+,14?,18?
InChIKey	DREIJXJRTLTGJC-JQCLMNFQSA-N
Smiles	C1C2CC3CC(C2)(CC1C3NC4=C5C=CNC5=NC=C4C(=O)N)O
Isomeric SMILES	C1[C@@H]2CC3(C[C@@H](C2NC4=C5C=CNC5=NC=C4C(=O)N)CC1C3)O
PubChem CID	57928403
Molecular Weight	326.39

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
F2313934	Certificate of Analysis	Mar 04, 2025	P413804
F23131303	Certificate of Analysis	Mar 04, 2025	P413804
F2313927	Certificate of Analysis	Mar 04, 2025	P413804
F2313949	Certificate of Analysis	Mar 04, 2025	P413804
F2313931	Certificate of Analysis	Mar 04, 2025	P413804

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 65 mg/mL (199.14 mM); Water: Insoluble; Ethanol: Insoluble;
Molecular Weight	326.400 g/mol
XLogP3	1.900
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	326.174 Da
Monoisotopic Mass	326.174 Da
Topological Polar Surface Area	104.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	525.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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